Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression

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成果类型：

期刊论文

作者：

Gong, Duo;Zhang, Qiang;Chen, Ling-yan;Yu, Xiao-Hua;Wang, Gang;...

通讯作者：

Yin, Wei-dong;Tang, Chao-ke

作者机构：

[Gong, Duo; Tang, Chao-ke; Yin, Wei-dong; Tang, CK; Yu, Xiao-Hua; Zhang, Qiang; Wang, Gang; Zou, Jin; Chen, Ling-yan] Univ South China, Med Res Expt Ctr, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

[Zheng, Xi-Long] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.

通讯机构：

[Yin, WD; Tang, CK] U

Univ South China, Med Res Expt Ctr, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

AS;CCDC80;DNA methylation;LPL;TET2

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2019

卷：

843

期：

页码：

177-189

DOI：

10.1016/j.ejphar.2018.11.009

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (81570408 and 81773736), Supported by University of South China Innovation Foundation for Postgraduate (2017XCX03).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Recent studies showed that coiled-coil domain-containing 80 (CCDC80) has a positive link with atherosclerosis and that plasma CCDC80 levels are positively correlated with the levels of fasting plasma triglycerides (TG) in obese individuals. The underlying mechanisms, however, are unclear. Using Hematoxylin-eosin (H&E) and Oil Red O staining, we found that CCDC80 overexpression in vivo significantly increased plasma lipid contents, decreased the expression and activity of lipoprotein lipase (LPL), and accelerated the development of atherosclerosis. Conversely, knockdown of CCDC80 decreased plaq...

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Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression

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