National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273537]; key disciplines of Hunan Province
机构署名：
本校为第一且通讯机构
院系归属：
药学与生物科学学院
摘要：
A novel series of apigenin derivatives with phloroglucinol or resorcinol as raw materials were synthesized according to Baker-Venaktaraman reaction and their in vitro inhibitory activities on colorectal adenocarcinoma (HT-29) and leucocythemia (HL-60) cell lines were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The results of biological test showed that some of apigenin derivatives possessed stronger anti-cancer activities than apigenin. Compound 6 showed the strongest activity against colorectal adenocarcinoma (HT-29) an...
