期刊论文

You Xiaoxing

英文

Chemico-Biological Interactions

0009-2797

2019

306

10-18

10.1016/j.cbi.2019.04.007

This work was supported by the National Natural Science Foundation of China ( 31670177 ), Foundation of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control (No. 2014-5 ), Construct Program of the Key Discipline in Hunan Province (No. 2011–75 ), and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study ( 2015-351 ). We appreciate the technical assistance of Kang Zheng and Zhifeng Long (University of South China) during the histopathological analysis.

本校为第一且通讯机构

Exposure to Mycoplasma pneumoniae leads to lung inflammation through a host defense pathway. Increasing evidence has indicated that the mycoplasma-derived membrane lipoprotein, or its analogue macrophage-activating lipopeptide-2 (MALP-2), excretes LPS as an immune system-stimulating substance and plays a crucial role in pathological injury during M. pneumoniae infection. It has been established that Sulforaphane confers anti-inflammatory properties. However, the underlying mechanism responsible for the inhibitory actions of Sulforaphane in the context of mycoplasmal pneumoniae are poorly under...