Heat Treatment Promotes Ubiquitin-Mediated Proteolysis of SARS-CoV-2 RNA Polymerase and Decreases Viral Load

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成果类型：

期刊论文

作者：

Maimaitiyiming, Yasen;Yang, Tao;Wang, Qian Qian;Feng, Yan;Chen, Zhi;...

通讯作者：

Naranmandura, H;Hu, CG;Hsu, CH

作者机构：

[Yang, Tao; Naranmandura, Hua; Maimaitiyiming, Yasen; Wang, Qian Qian] Zhejiang Univ, Affiliated Hosp 1, Dept Publ Hlth, Sch Med, Hangzhou 310058, Peoples R China.

[Yang, Tao; Naranmandura, Hua; Maimaitiyiming, Yasen; Wang, Qian Qian] Zhejiang Univ, Affiliated Hosp 1, Dept Hematol, Sch Med, Hangzhou 310058, Peoples R China.

[Yang, Tao; Naranmandura, Hua; Maimaitiyiming, Yasen; Wang, Qian Qian] Zhejiang Univ, Canc Ctr, Hangzhou 310058, Peoples R China.

[Maimaitiyiming, Yasen] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Neurobiol, Hangzhou 310058, Peoples R China.

[Maimaitiyiming, Yasen] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Neurol, Hangzhou 310058, Peoples R China.

通讯机构：

[Hu, CG ; Naranmandura, H ; Hsu, CH ] Z

Zhejiang Univ, Affiliated Hosp 1, Dept Publ Hlth, Sch Med, Hangzhou 310058, Peoples R China.

Zhejiang Univ, Affiliated Hosp 1, Dept Hematol, Sch Med, Hangzhou 310058, Peoples R China.

Zhejiang Univ, Canc Ctr, Hangzhou 310058, Peoples R China.

Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou 310051, Peoples R China.

语种：

英文

期刊：

研究(英文)

ISSN：

2096-5168

年：

2022

卷：

2022

期：

页码：

40-44

DOI：

10.34133/2022/9802969

基金类别：

Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LD22H310005]; National Science and Technology Major Project of the Ministry of Science and Technology of China [2018ZX10302-206]; National Key RAMP;D Program of China [2021YFC2700903]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872942, 82000155, 82003875, 31972883]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2021M702877]; Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Despite extensive efforts, COVID-19 pandemic caused by the SARS-CoV-2 virus is still at large. Vaccination is an effective approach to curb virus spread, but several variants (e.g., delta, delta plus, omicron, and IHU) appear to weaken or possibly escape immune protection. Thus, novel and quickly scalable approaches to restrain SARS-CoV-2 are urgently needed. Multiple evidences showed thermal sensitivity of SARS-CoV-2 and negative correlation between environmental temperature and COVID-19 transmission with unknown mechanism. Here, we reveal a p...

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Heat Treatment Promotes Ubiquitin-Mediated Proteolysis of SARS-CoV-2 RNA Polymerase and Decreases Viral Load

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