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Mathematical modelling of the effects of statins on the growth of necrotic core in atherosclerotic plaque

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成果类型:
期刊论文
作者:
Lei, Weirui;Hu, Jiwen;Xie, Yaqian;Liu, Can;Chen, Xuekun
作者机构:
[Chen, Xuekun; Xie, Yaqian; Hu, Jiwen; Lei, Weirui; Liu, Can] Univ South China, Coll Math & Phys, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Statins;atherosclerosis;necrotic core volume;finite element method
期刊:
MATHEMATICAL MODELLING OF NATURAL PHENOMENA
ISSN:
0973-5348
年:
2023
卷:
18
页码:
11
基金类别:
the National Nature Science Foundation of China#&#&#Nos. 11747121 the National Nature Science Foundation of China#&#&#Nos. 11904161 the National Nature Science Foundation of China#&#&#Nos.12274200
机构署名:
本校为第一机构
院系归属:
数理学院
摘要:
A large necrotic core increases the risk of atherosclerotic plaque instability. Statins can delay the growth of necrotic core in plaques, but the kinetic mechanism of statins in slowing down the necrotic core has not yet been addressed in detail. In this paper, a mathematical model is governed by a system of advection-diffusion-reaction equations coupling of the porous nature of vessel wall is established and applied to illustrate the plaque growth with lipid-rich necrotic core (LRNC) with and without statins using finite element method. We study the influence of LRNC plaque growth for differe...

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