Objective To synthetize a variety of chrysin derivatives and identify their antitumor activity in vitro. Methods Chry-sin was applied as main raw materials and the 5-Bromosalicylic acid ester was added to the reaction system to synthesize chrysin derivatives in the etherification reaction. Then the MTT method was used to detect the anticancer activities of chrysin derivatives on human gastric cell line MGC-803 and human hepatocellular carcimoma cell HepG2. Results The 50%inhibiting concentrations of compounds2a,2band4aonHepG2cellswerelowerthanthatofchrysinin vitro.Meanwhile,the50%inhibitingcon...
