期刊论文

中文

肿瘤药学

2095-1264

2011

1

2

149-152

10.3969/j.issn.2095-1264.2011.02.019

本校为第一机构

目的探索苦参素及其制剂不良反应发生的流行病学特点。方法通过检索2000～2010年医药期刊和利用全国药物不良反应监测中心的省级ADR中心网页检索,共收集苦参素不良反应详细病案57例;在构建数据库的基础上,应用统计学方法对相关信息进行分析。结果苦参素不良反应,男性、女性发生率大致相同,发生不良反应的年龄以30～70岁为主,不良反应主要发生时间在用药后60min内,发生不良反应的剂型多以注射液,占（93.0%）。不良反应的主要类型是消化系统损害12例（20.0%）,其次是免疫系统反应11例（18.3%）、皮肤及附件系统10例（16.7%）、呼吸系统8例（13.3%）等。结论消化系统反应是苦参素制剂最常见的不良反...

Objective To investigate the epidemiological characteristics of adverse reaction caused by Oxymatrine. Method 57 cases of Oxymatrine adverse reactions were collected by searching medical journals from 2000 to 2010 and web of provincial ADR center in National Center for Adverse Drug Reaction Monitoring,; based on the database, statistical methods were applied to analyse the related information. Results There is no obviously distinction in different gender in adverse reactions of Oxymatrine. Main adverse reactions events occurred at the age range...