期刊论文

Progress of Codilin on Cell Migration

中文

中华全科医学

1674-4152

2009

7

6

646-648

10.16766/j.cnki.issn.1674-4152.2009.06.011

本校为第一机构

Cofilin（丝切蛋白）是普遍存在于真核细胞的一种肌动蛋白结合蛋白。Cofilin的基本功能是在细胞内结合和解聚F-肌动蛋白（F-actin）,其活性是通过磷酸化、去磷酸化、磷酸肌醇、pH改变等进行调节。Cofilin介导了细胞内的信号途径,从而调节肌动蛋白骨架的重组,对细胞迁移起到重要作用。细胞运动中的每个步骤都受到精巧的调节控制,以保证原料和能量的合理利用和细胞迁移的有效进行。Cofilin正是在这一调节中起作用的一个蛋白。肿瘤细胞的转移是肿瘤发生发展的一个关键环节,本文根据目前对Cofilin的研究结果,从Cofilin在细胞迁移及肿瘤细胞转移中的作用作以综述。

Cofilin is a kind of actin binding proteins common in eukaryotic cells. The basic function of Cofilin is to bind with F-actin and then disassemble F-actin. And the activity of Cofilin is regulated by phosphorylation, dephosphorylation, phos- phoinositide and pH value. Cofilin mediates the intracellular signal pathway and thus regulates the reassemble of actin skeleton and play a vital role in cell migration. In the process of cell migration, each step is modulated delicately to make sure the material and energy optimally used and cell migrating efficiently. And Cofilin functions as a regulator...