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Neuroglobin is capable of self-oxidation of methionine64 introduced at the heme axial position

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成果类型:
期刊论文
作者:
Liu, Hai-Xiao;Li, Lianzhi;He, Bo;Gao, Shu-Qin;Wen, Ge-Bo;...
通讯作者:
Lin, Ying-Wu
作者机构:
[Lin, Ying-Wu; He, Bo; Liu, Hai-Xiao] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
[Li, Lianzhi] Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Peoples R China.
[Gao, Shu-Qin; Wen, Ge-Bo; Lin, Ying-Wu] Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.
通讯机构:
[Lin, Ying-Wu] U
Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
Univ South China, Lab Prot Struct & Funct, Hengyang 421001, Peoples R China.
语种:
英文
期刊:
DALTON TRANSACTIONS
ISSN:
1477-9226
年:
2018
卷:
47
期:
32
页码:
10847-10852
基金类别:
We gratefully thank Prof. T. Burmester of the Gutenberg University of Mainz, Germany, for graciously providing the gene of human Ngb. Low temperature EPR studies were performed on the Steady High Magnetic Field Facilities, High Magnetic Field Laboratory, CAS (Hefei, China). This work was supported by the National Natural Science Foundation of China, NSFC (31370812; 21701081).
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
摘要:
Neuroglobin (Ngb), with its physiological role not fully understood, was found to be capable of self-oxidation of methionine64 introduced at the heme axial position (H64M Ngb), adopting a high-spin heme state and producing both methionine sulfoxide (SO-Met) and sulfone (SO2-Met), which represents the structure and functio...

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