PERP gene therapy attenuates lung cancer xenograft via inducing apoptosis and suppressing VEGF

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成果类型：

期刊论文

作者：

Chen, Ke*;Luo, Zhaoyang;Li, Zhongwu;Liu, Yiqiang;Zhao, Qingzheng

通讯作者：

Chen, Ke

作者机构：

[Chen, Ke] Chinese Acad Sci, Lab Dis Genom & Personalized Med, Beijing Inst Genom, Beijing, Peoples R China.

[Chen, Ke; Zhao, Qingzheng] Chinese Acad Med Sci, Dept Cellular & Mol Biol, Canc Inst & Hosp, Beijing 100730, Peoples R China.

[Chen, Ke; Zhao, Qingzheng] Peking Union Med Coll, Beijing 100021, Peoples R China.

[Chen, Ke; Luo, Zhaoyang] Univ S China, Inst Canc Res, Hengyang City, Peoples R China.

[Li, Zhongwu; Liu, Yiqiang] Peking Univ, Dept Pathol, Beijing Canc Hosp & Inst, Sch Oncol, Beijing 100871, Peoples R China.

通讯机构：

[Chen, Ke] C

Chinese Acad Sci, Lab Dis Genom & Personalized Med, Beijing Inst Genom, Beijing, Peoples R China.

语种：

英文

关键词：

Apoptosis;Caspase-3;Gene therapy;Lung cancer;PERP;Smac;TRAIL;VEGF

期刊：

Cancer Biology & Therapy

ISSN：

1538-4047

年：

2011

卷：

期：

页码：

1114-1119

DOI：

10.4161/cbt.12.12.18435

基金类别：

Figure 2B. The tumor volume was calculated using the formula: This work was supported by a grant from National Natural Volume = S Ä S Ä L/2, where S is the short length of the tumor Science Foundation of China (81101940). We thank Jing Wu for in cm and L is the long length of the tumor in cm. editing the manuscript and Jietao Song for help with animal care.

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Inducing apoptosis is an attractive antitumor strategy. PERP is an apoptosis-associated target of p53, and its activation alone is sufficient to induce apoptotic pathway leading to cell death. We have previously demonstrated that overexpression of PERP in tumor cell lines with low intrinsic PERP activity suppressed cancer cell growth and enhanced sensitivity to chemotherapeutical agents. We further identified that PERP was present in surgical normal lung tissue, but absent in cancerous tissue of the same patient. Here, we sought to investigate the anti-tumor effects of PERP gene therapy in viv...

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PERP gene therapy attenuates lung cancer xenograft via inducing apoptosis and suppressing VEGF

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