Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yan, Binjie;Belke, Darrell;Gui, Yu;Chen, Yong-Xiang;Jiang, Zhi-Sheng;...

通讯作者：

Zheng, XL;Jiang, ZS

作者机构：

[Gui, Yu; Zheng, Xi-Long; Yan, Binjie; Zheng, XL] Univ Calgary, Cumming Sch Med, Dept Biochem & Mol Biol, Calgary, AB T2N 4Z6, Canada.

[Gui, Yu; Zheng, Xi-Long; Yan, Binjie; Zheng, XL] Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB T2N 4Z6, Canada.

[Jiang, Zhi-Sheng; Jiang, ZS; Yan, Binjie] Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

[Belke, Darrell; Chen, Yong-Xiang] Univ Calgary, Cumming Sch Med, Dept Cardiac Sci, Calgary, AB, Canada.

通讯机构：

[Jiang, ZS ; Zheng, XL ] U

Univ Calgary, Cumming Sch Med, Dept Biochem & Mol Biol, Calgary, AB T2N 4Z6, Canada.

Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB T2N 4Z6, Canada.

Univ South China, Inst Cardiovasc Dis, Hengyang Med Sch, Key Lab Arteriosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

语种：

英文

期刊：

Cell Death Discovery

ISSN：

2058-7716

年：

2023

卷：

期：

页码：

456

DOI：

10.1038/s41420-023-01748-9

基金类别：

Canadian Institutes of Health Research (CIHR, PJT-178010 to XLZ, PJT-165941 to XLZ) and the Natural Sciences and Engineering Research Council of Canada (RGPIN-2020-04592 to XLZ) [PJT-178010, PJT-165941]; Canadian Institutes of Health Research (CIHR) [RGPIN-2020-04592]; Natural Sciences and Engineering Research Council of Canada; China Scholarship Council (CSC) Studentship

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a human paracaspase protein with proteolytic activity via its caspase-like domain. The pharmacological inhibition of MALT1 by MI-2, a specific chemical inhibitor, diminishes the response of endothelial cells to inflammatory stimuli. However, it is largely unknown how MALT1 regulates the functions of vascular smooth muscle cells (SMCs). This study aims to investigate the impact of MALT1 inhibition by MI-2 on the functions of vascular SMCs, both in vitro and in vivo. MI-2 treatment led to concentration- and time-depend...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问