Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Yong;Huang, Shengping;Huang, Xuan;Li, Xiuzhen;Falcon, Adrian;...

通讯作者：

Fu, Mingui

作者机构：

[Li, Xiuzhen; Huang, Shengping; Falcon, Adrian; Soutar, Adele; Li, Yong; Fu, Mingui; Huang, Xuan] Univ Missouri, Sch Med, Dept Biomed Sci, 2411 Holmes St, Kansas City, MO 64108 USA.

[Li, Xiuzhen; Huang, Shengping; Falcon, Adrian; Soutar, Adele; Li, Yong; Fu, Mingui; Huang, Xuan] Univ Missouri, Sch Med, Shock Trauma Res Ctr, 2411 Holmes St, Kansas City, MO 64108 USA.

[Xin, Hong-Bo; Li, Yong; Huang, Xuan] Nanchang Univ, Inst Translat Med, 999 Xuefu Rd, Nanchang 330031, Jiangxi, Peoples R China.

[Bornancin, Frederic] Novartis Inst BioMed Res, Novartis Campus, Basel, Switzerland.

[Jiang, Zhisheng] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Fu, Mingui] U

Univ Missouri, Sch Med, Dept Biomed Sci, 2411 Holmes St, Kansas City, MO 64108 USA.

Univ Missouri, Sch Med, Shock Trauma Res Ctr, 2411 Holmes St, Kansas City, MO 64108 USA.

语种：

英文

关键词：

*Endothelial activation;*Inhibitors of MALT1;*MCPIP1, vascular inflammation;*VCAM-1

期刊：

Cellular Signalling

ISSN：

0898-6568

年：

2018

卷：

页码：

1-8

DOI：

10.1016/j.cellsig.2018.05.009

基金类别：

National Institutes of Health grantsUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AI103618]; American Heart Association grantAmerican Heart Association [17AIREA33660073]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670429]; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R21AI103618, R21AI103618] Funding Source: NIH RePORTER

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Mucosa associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is not only an intracellular signaling scaffold protein but also a paracaspase that plays a key role in the signal transduction and cellular activation of lymphocytes and macrophages. However, its role in endothelial cells remains unknown. Here we report that pharmacological inhibition of MALT1 protease activity strongly suppresses endothelial activation via enhancing MCPIP1 expression. Treatment with MALT1 protease inhibitors selectively inhibited TNFα-induced VCAM-1 e...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问