期刊论文

Xiao, Ji

英文

International Immunopharmacology

1567-5769

2020

89

Pt A

107000

10.1016/j.intimp.2020.107000

CRediT authorship contribution statement Jiazheng Wang: Methodology, Resources, Data curation, Project administration. Min Luo: Investigation, Data curation. Jiafan Shen: Resources, Project administration. Zhiwen Liu: Methodology, Investigation. Ying Chen: Validation, Formal analysis. Jie Luo: Project administration, Data curation. Zhiying Zeng: Validation, Formal analysis. Dinling Deng: Investigation, Data curation. Ji Xiao: Conceptualization, Supervision, Writing - original draft, acquisition.

本校为第一且通讯机构

Bakuchiol (BAK) is a prenylated phenolic mono-terpene extracted from the fruit of Psoralea corylifolia L., which exerts a protective effect on organs. However, whether BAK has a protective effect on sepsis-induced acute kidney injury (S-AKI) is not clear. In our study we have demonstrated for the first time that pretreatment with BAK significantly reduced bacterial load, inflammation and renal oxidative stress in caecal ligation and puncture (CLP)-induced sepsis. Moreover, CLP-induced renal histological damage, mortality and clinical signs were...