Identification of differentially expressed proteins in the gastric mucosal atypical hyperplasia tissue microenvironment

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成果类型：

期刊论文

作者：

Zhang, He-Liang;Liu, Chong-Yuan;Ma, Wei;Huang, Lin;Li, Chang-Jian;...

通讯作者：

Zhang, Zhi-Wei

作者机构：

[Zhang, He-Liang; Ma, Wei; Liu, Chong-Yuan; Zhang, Zhi-Wei] Univ South China, Canc Res Inst, Med Coll, Key Lab Canc Cellular & Mol Pathol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Zhang, He-Liang] Med Co, Troops 66028 Peoples Liberat Army, Chengde 067000, Hebei, Peoples R China.

[Huang, Lin] Shaoyang Med Sch, Dept Pediat, Shaoyang 422000, Hunan, Peoples R China.

[Li, Cheng-Song; Li, Chang-Jian] Univ South China, Med Coll, Clin Med Undergrad Program, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zhang, Zhi-Wei] U

Univ South China, Canc Res Inst, Med Coll, Key Lab Canc Cellular & Mol Pathol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

gastric mucosal atypical hyperplasia;microenvironment;protein expression

期刊：

ONCOLOGY LETTERS

ISSN：

1792-1074

年：

2018

卷：

期：

页码：

2355-2365

DOI：

10.3892/ol.2018.8941

基金类别：

Hunan Provincial Innovation Foundation For Postgraduates [CX2016B478]; Doctoral Research Start-Up Fund of the University of South China [2016XQD21]; Hunan Provincial Groundbreaking Platform Open Fund of the University of China [10K052, 12K094, 13K083]; Hunan Provincial Education Department Foundation of China [11C1112, 12C0340]; Hunan Provincial Health Department Foundation of China [B2013-048, 2014-163]; Construct Program of the Key Discipline in Hunan Province of China [2011-76]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

In the present study, the interaction of proteins in the microenvironment of gastric mucosal atypical hyperplasia was analyzed. The stromata of normal gastric mucosa (NGM) and gastric mucosal atypical hyperplasia (GMAH) tissues were purified with laser capture microdissection (LCM). The differentially expressed GMAH proteins of the NGM and GMAH tissues were identified by quantitative proteomic techniques with isotope labeling. The cross-talk between differentially expressed proteins in NGM and GMAH tissues was then analyzed by bioinformatics. There were 165 differentially expressed proteins id...

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Identification of differentially expressed proteins in the gastric mucosal atypical hyperplasia tissue microenvironment

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