Nrf2 regulates the inflammatory response, including heme oxygenase-1 induction, by mycoplasma pneumoniae lipid-associated membrane proteins in THP-1 cells

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成果类型：

期刊论文

作者：

Hu, Jihong;Chen, Chunyan;Ou, Guangli;You, Xiaoxing;Tan, Tianping;...

通讯作者：

Zhu, Cuiming

作者机构：

[Tan, Tianping; Chen, Chunyan; Ou, Guangli; Hu, Jihong; Zhu, Cuiming; Zeng, Yihua; Hu, Xinnian; You, Xiaoxing; Yu, Minjun] Univ South China, Inst Pathogen Biol, Med Coll, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Tan, Tianping; Chen, Chunyan; Ou, Guangli; Hu, Jihong; Zhu, Cuiming; Zeng, Yihua; Hu, Xinnian; You, Xiaoxing; Yu, Minjun] Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

[Hu, Jihong; Zhu, Cuiming] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

通讯机构：

[Zhu, Cuiming] U

Univ South China, Inst Pathogen Biol, Med Coll, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

heme oxygenase 1;immunologic factor;lipid linked protein;NFE2L2 protein, human;nitric oxide;reactive oxygen metabolite;transcription factor Nrf2;biosynthesis;human;immunological tolerance;immunology;inflammation;metabolism;monocyte;Mycoplasma pneumoniae;THP-1 cell line;Heme Oxygenase-1;Humans;Immune Tolerance;Immunologic Factors;Inflammation;Lipid-Linked Proteins;Monocytes;Mycoplasma pneumoniae;NF-E2-Related Factor 2;Nitric Oxide;Reactive Oxygen Species;THP-1 Cells

期刊：

Pathogens and Disease

ISSN：

0928-8244

年：

2017

卷：

期：

DOI：

10.1093/femspd/ftx044

基金类别：

This work was supported by the Foundation of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (No. 2014–5), the construct program of the key discipline in Hunan province for Preclinical Medicine and Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (No. 2012-1 and 2014-405), and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015-351).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

A series of inflammatory responses caused by Mycoplasma pneumoniae largely depend on the lipid-associated membrane proteins (LAMPs). Nuclear factor E2-related factor 2 (Nrf2), a transcription factor, is considered to be a critical modulator of inflammatory responses and cellular redox homeostasis. Monocytes play an important role in the invasion and immunity to resist pathogens. Here, we investigated the role of Nrf2 in the anti-inflammatory response stimulated by LAMPs using the human monocyte cell line THP-1. LAMPs were shown to affect the lo...

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Nrf2 regulates the inflammatory response, including heme oxygenase-1 induction, by mycoplasma pneumoniae lipid-associated membrane proteins in THP-1 cells

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