Apelin/APJ system: an emerging therapeutic target for neurological diseases

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成果类型：

期刊论文

作者：

Li, Ao;Zhao, Qun;Chen, Linxi;Li, Zhiyue

通讯作者：

Linxi Chen<&wdkj&>Zhiyue Li

作者机构：

[Li, Ao; Chen, Linxi] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Inst Pharm & Pharmacol,Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhao, Qun] Cent South Univ, Xiangya Hosp 3, Hlth Management Ctr, Changsha, Hunan, Peoples R China.

[Li, Zhiyue] Cent South Univ, Dept Orthoped, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.

通讯机构：

[Linxi Chen] I

[Zhiyue Li] D

Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, China<&wdkj&>Department of Orthopedics, Third Xiangya Hospital of Central South University, Changsha, China

语种：

英文

关键词：

apelin;apelin receptor;apelin;apelin receptor;G protein coupled receptor;Alzheimer disease;cerebrovascular disease;degenerative disease;depression;epilepsy;glioblastoma;human;ischemic stroke;nervous system;neurologic disease;nonhuman;pain;Parkinson disease;pathogenesis;psychosis;Review;subarachnoid hemorrhage;traumatic brain injury;brain injury;degenerative disease;metabolism;oxidative stress;Apelin;Apelin Receptors;Brain Injuries;Humans;Neurodegenerative Diseases;Oxidative Stress;Receptors, G-Protein-Coupled

期刊：

Molecular Biology Reports

ISSN：

0301-4851

年：

2023

卷：

期：

页码：

1639-1653

DOI：

10.1007/s11033-022-08075-9

基金类别：

The study was supported by grants from the National Natural Science Foundation of China (81973326), Hunan Provincial Natural Science Foundation (2019JJ40255) Funding was provided by National Natural Science Foundation of China (81973326) and Natural Science Foundation of Hunan Province (2019JJ40255)

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Apelin, an endogenous ligand for the G protein-coupled receptor APJ, is extensively expressed in various systems, especially the nervous system. This article reviews the role of apelin/APJ system in neurological diseases. In detail, apelin/APJ system can relieve acute brain injury including subarachnoid hemorrhage, traumatic brain injury, and ischemic stroke. Also, apelin/APJ system has therapeutic effects on chronic neurodegenerative disease models, involving the regulation of neurotrophic factors, neuroendocrine, oxidative stress, neuroinflam...

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