期刊论文

Advances of the mechanisms of long non-coding RNAs involved in the immune regulation of rheumatoid arthritis

中文

中国临床药理学杂志

1001-6821

2018

34

22

2654-2656

10.13699/j.cnki.1001-6821.2018.22.020

湖南省自然科学基金资助项目（2017JJ2226）；

本校为第一机构

长链非编码RNAs是一类转录本长度超过200 nt、不能编码蛋白的RNAs。lncRNAs表达紊乱或调节失常可通过多途径、多层次广泛参与风湿性疾病的免疫应答、细胞分化及发生发展。因此,lncRNAs有望成为类风湿关节炎治疗的潜在靶点,为逆转类风湿关节炎的治疗提供新思路、新策略。

Long non -coding RNAs （lncRNAs） are RNAs with a tran- script length of more than 200 nt and no encoded protein function. In re- cent years, studies have shown that disturbance of lncRNAs expression or deregulation can be widely involved in rheumatoid immune responses, cell differentiation, and development through multiple patbways and levels. Therefore, lncRNAs are expected to become potential targets for the treatment of rheumatoid arthritis and provide new ideas and new s trat...