We would like to acknowledge financial support from the project of Hunan Provincial Health Bureau (C2013-008) and the start-up Grant from the University of South China (2013XQD22). This work was also partially supported by Zhengxiang Scholar Program of the University of South China (Xiangyang Tang) and construct program of the key discipline in Hunan province.
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
The purpose of the present study was to investigate whether ketamine’s rapid antidepressant effects were associated with its anti-inflammatory actions and to explore the underlying molecular mechanism. Depressive-like behaviors was induced in mice using chronic restraint stress (CRS) method. Anti-depressive effects of ketamine were evaluated by forced swimming tests (FST) and sucrose preference test (SPT). Subsequently, brain tissue was harvested to investigate inflammatory response in the hippocampus via investigating reactive microglia numbe...
