期刊论文

Chun-yan Wu<&wdkj&>Lu-shan Liu

英文

Biomedicine & Pharmacotherapy

0753-3322

2023

158

114106

10.1016/j.biopha.2022.114106

The work was granted by the Natural Science Foundation of Hunan province (grant number 2021JJ30596 ), the Excellent Youth Project of the Education Department of Hunan Province (grant number 18B283 ), Scientific Research Project of Hunan Provincial Health Commission (grant number 202102060995 ), International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province (grant number 2018WK4031 ), Research and Innovation Project of Postgraduates in Hunan Province (grant number QL20210231 ), Undergraduate Innovative Experiment Project (grant number 202110555101 , 202110555093 , X2019133 ).

本校为第一机构

Heart failure (HF) is a complex clinical syndrome caused by various cardiovascular diseases. Its main pathogenesis includes cardiomyocyte loss, myocardial energy metabolism disorder, and activation of cardiac inflammation. Due to the clinically unsatisfactory treatment of heart failure, different mechanisms need to be explored to provide new targets for the treatment of this disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a gene mainly related to familial hypercholesterolemia, was discovered in 2003. Aside from regulating lipid metabolism, PCSK9 may be involved in other biologi...