Administration of metformin alleviates atherosclerosis by promoting H2S production via regulating CSE expression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ma, Xiaofeng;Jiang, Zhisheng*;Wang, Zuo;Zhang, Zhuhua

通讯作者：

Jiang, Zhisheng

作者机构：

[Ma, Xiaofeng; Jiang, Zhisheng; Wang, Zuo] Univ South China, Inst Cardiovasc Dis, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

[Ma, Xiaofeng; Jiang, Zhisheng; Wang, Zuo] Univ South China, Key Lab Arteriosclerol Hunan, Hengyang, Hunan, Peoples R China.

[Ma, Xiaofeng] Univ South China, Affiliated Nanhua Hosp, Dept Cardiol, Hengyang, Hunan, Peoples R China.

[Zhang, Zhuhua] Beijing Hosp Tradit Chinese Med, Dept Cardiol, Beijing, Peoples R China.

[Jiang, Zhisheng] Univ South China, Key Lab Arteriosclerol Hunan Prov, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Jiang, Zhisheng] U

Univ South China, Inst Cardiovasc Dis, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Key Lab Arteriosclerol Hunan Prov, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

atherosclerosis;cystathionine γ-lyase (CSE);homocystein;hydrogen sulfide (H2S);macrophage;Met

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2020

卷：

235

期：

页码：

2102-2112

DOI：

10.1002/jcp.29112

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

The therapeutic effect of metformin (Met) on atherosclerosis was studied here. Effects of methionine and Met on the induction of inflammatory response and H2S expression in peritoneal macrophages were evaluated. Enzyme-linked immunosorbent assay, immunohistochemistry assay, western blot, and quantitative reverse transcription polymerase chain reaction were conducted to observe the levels of cystathionine gamma-lyase (CSE), DNA methyltransferases 1 (DNMT1), DNMT3a, DNMT3b, tumor necrosis factor (TNF- alpha), interleukin 1b (IL-1 beta), and hydrogen sulfide (H2S). Luciferase and bisulfite sequen...

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Administration of metformin alleviates atherosclerosis by promoting H2S production via regulating CSE expression

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