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Administration of metformin alleviates atherosclerosis by promoting H2S production via regulating CSE expression

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成果类型:
期刊论文
作者:
Ma, Xiaofeng;Jiang, Zhisheng*;Wang, Zuo;Zhang, Zhuhua
通讯作者:
Jiang, Zhisheng
作者机构:
[Ma, Xiaofeng; Jiang, Zhisheng; Wang, Zuo] Univ South China, Inst Cardiovasc Dis, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
[Ma, Xiaofeng; Jiang, Zhisheng; Wang, Zuo] Univ South China, Key Lab Arteriosclerol Hunan, Hengyang, Hunan, Peoples R China.
[Ma, Xiaofeng] Univ South China, Affiliated Nanhua Hosp, Dept Cardiol, Hengyang, Hunan, Peoples R China.
[Zhang, Zhuhua] Beijing Hosp Tradit Chinese Med, Dept Cardiol, Beijing, Peoples R China.
[Jiang, Zhisheng] Univ South China, Key Lab Arteriosclerol Hunan Prov, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Jiang, Zhisheng] U
Univ South China, Inst Cardiovasc Dis, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Key Lab Arteriosclerol Hunan Prov, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
cystathionine gamma lyase;DNA (cytosine 5) methyltransferase 1;DNA methyltransferase 3A;DNA methyltransferase 3B;homocysteine;hydrogen sulfide;interleukin 1beta;messenger RNA;metformin;methionine;tumor necrosis factor;cystathionine gamma lyase;hydrogen sulfide;interleukin 1beta;metformin;tumor necrosis factor;amino acid blood level;animal experiment;animal model;animal tissue;Article;atherosclerosis;bisulfite sequencing;C57BL 6 mouse;controlled study;cytokine production;disease severity;DNA methylation;drug effect;inflammation;luciferase assay;male;mouse;mRNA expression level;nonhuman;peritoneum macrophage;priority journal;promoter region;protein expression level;RAW 264.7 cell line;synthesis;THP-1 cell line;animal;atherosclerosis;C57BL mouse;cell line;metabolism;signal transduction;Animals;Atherosclerosis;Cell Line;Cystathionine gamma-Lyase;DNA Methylation;Hydrogen Sulfide;Interleukin-1beta;Macrophages, Peritoneal;Male;Metformin;Mice;Mice, Inbred C57BL;Promoter Regions, Genetic;RAW 264.7 Cells;Signal Transduction;Tumor Necrosis Factor-alpha
期刊:
JOURNAL OF CELLULAR PHYSIOLOGY
ISSN:
0021-9541
年:
2020
卷:
235
期:
3
页码:
2102-2112
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
The therapeutic effect of metformin (Met) on atherosclerosis was studied here. Effects of methionine and Met on the induction of inflammatory response and H2S expression in peritoneal macrophages were evaluated. Enzyme-linked immunosorbent assay, immunohistochemistry assay, western blot, and quantitative reverse transcription polymerase chain reaction were conducted to observe the levels of cystathionine γ-lyase (CSE), DNA methyltransferases 1 (DNMT1), DNMT3a, DNMT3b, tumor necrosis factor (TNF- α), interleukin 1b (IL-1β), and hydrogen sulfi...

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