Micelles with Cyclic Poly(epsilon-caprolactone) Moieties: Greater Stability, Larger Drug Loading Capacity, and Slower Degradation Property for Controlled Drug Release.

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Kang, Guiying;Sun, Lu;Liu, Yuping;Meng, Chao;Ma, Wei;...

通讯作者：

Wei, Hua;Yu, Cuiyun

作者机构：

[Liu, Yuping; Wei, Hua; Ma, Wei; Ma, Liwei; Sun, Lu; Wang, Baoyan; Meng, Chao; Kang, Guiying] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

[Liu, Yuping; Wei, Hua; Ma, Wei; Ma, Liwei; Sun, Lu; Wang, Baoyan; Meng, Chao; Kang, Guiying] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

[Wei, Hua; Yu, Cuiyun; Wei, H] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Wei, Hua; Yu, Cuiyun; Wei, H] Univ South China, Dept Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Wei, Hua] L

[Yu, CY; Wei, H] U

Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Copper compounds;Cyclization;Ethylene;Hydrophobicity;Loading;Micelles;Motion Picture Experts Group standards;Polyethylene oxides;Ring opening polymerization;Targeted drug delivery;Topology;Amphiphilic diblock copolymers;Azide-alkyne cycloaddition;Controlled drug release;Drug delivery applications;Drug loading capacity;Hydrophobic moieties;Self-assembly behaviors;Topological effects;Controlled drug delivery;doxorubicin;drug carrier;macrogol;polycaprolactone;polyester;chemistry;delayed release formulation;HeLa cell line;human;kinetics;micelle;Delayed-Action Preparations;Doxorubicin;Drug Carriers;HeLa Cells;Humans;Kinetics;Micelles;Polyesters;Polyethylene Glycols

期刊：

LANGMUIR

ISSN：

0743-7463

年：

2019

卷：

期：

页码：

12509-12517

DOI：

10.1021/acs.langmuir.9b02346

基金类别：

The authors acknowledge the financial support from the National Natural Science Foundation of China (51473072 and 21504035), the Thousand Young Talent Program, the Outstanding Youth Fund of Natural Science Foundation of Hunan Province (2017JJ1024), the National Key R&D Program of China (2018YFB1900201), and the Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences.

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

Polymer topology exerts a significant effect on its properties and performance for potential applications. Cyclic topology and its derived structures have been recently shown to outperform conventional linear analogues for drug delivery applications. However, an amphiphilic tadpole-shaped copolymer consisting of a cylic hydrophobic moiety has rarely been explored. For this purpose, a tadpole-shaped amphiphilic diblock copolymer of poly(ethylene oxide)-b-(cyclic poly(ϵ-caprolactone)) (mPEG-b-cPCL) was synthesized successfully via ring-opening p...

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Micelles with Cyclic Poly(epsilon-caprolactone) Moieties: Greater Stability, Larger Drug Loading Capacity, and Slower Degradation Property for Controlled Drug Release.

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