期刊论文

Interleukins in Chlamydia infection: An update

中文

细胞与分子免疫学杂志

1007-8738

2021

37

01

84-89

10.13423/j.cnki.cjcmi.009137

南华大学2019年研究生科研创新项目（193YXC025）；

本校为第一机构

衣原体（Chlamydia）感染仍是世界面临的难题,数亿人口因衣原体感染引起相关疾病,但具体感染机制尚不清楚。研究表明,白细胞介素参与衣原体感染后机体固有免疫过程。在感染初期,衣原体通过受体介导的多种信号转导通路如丝裂原活化蛋白激酶（MAPK）、信号转导子与转录激活子3（STAT3）、髓样分化因子88（MyD88）通路等,促使机体释放多种促炎白细胞介素如白细胞介素1β（IL-1β）、 IL-6、 IL-8和IL-17等,抑制衣原体复制,加速清除衣原体。随着促炎白细胞介素的持续分泌,机体调控免疫细胞分泌抗炎性白细胞介素如IL-4、 IL-10和IL-22等,减轻炎症反应,减少组织损伤。我们总结了衣原体感染疾病中白细胞...

Chlamydia infection remains a problem for the world. Hundreds of millions of people suffer from Chlamydiarelated diseases,but the specific infection mechanism is still unclear. Studies have shown that interleukins is involved in the innate immune process after Chlamydia infection. In the early stage of infection,Chlamydia,through receptor-mediated multiple signal transduction pathways,such as mitogen-activated protein kinase (MAPK),signal transducers and activators of transcription 3 (STAT3),myeloid differentiation factor 88 (MyD88) pathways,pr...