期刊论文

Yu, Y.

中文

细胞与分子免疫学杂志

1007-8738

2014

30

8

793-797

10.13423/j.cnki.cjcmi.006968

国家自然科学基金（30770155） 湖南省自然科学基金（12JJ3105）

本校为其他机构

目的研究盐酸吡格列酮对糖尿病大鼠肾组织Toll样受体4(TLR4)表达的影响。方法57只雄性SD大鼠,分为实验组(n =48)和正常对照组(n=9)。实验组大鼠腹腔注射链脲佐菌素(STZ)50 mg/kg建立糖尿病大鼠模型,正常对照组注射等剂量无菌枸橼酸钠缓冲液。建模成功的45只大鼠随机分为5组,每组9只。吡格列酮5 mg/(kg ? d)、吡格列酮10 mg/(kg ? d)组、吡格列酮5 mg/(kg? d)联合TLR4特异性抑制剂Eritoran 5 mg/(kg ? d)、吡格列酮10 mg/(kg ? d)联合TLR4特异性抑制剂Eritoran 5 mg/(kg ? d),未干预组。吡格列酮采用灌胃的方法给药,对照组给予等量生理盐水灌胃。联合应用TLR4特异性抑制剂Eritoran组于第5周给予腹...

OBJECTIVE: To investigate the effect of pioglitazone on the expression of Toll-like receptor 4 (TLR4) in renal tissue of diabetic rats. METHODS: The male Sprague Dawlry rats (n=57) were randomly divided into the control group (n=9) and experimental group (n=48). The experimental rats were injected introperatoneally with 50 mg/kg streptozotocin (STZ) and the controls were given sodium citrate buffer instead. Then the experimental rats were randomized into five groups: pioglitazone 5 mg/(kg.d), pioglitazone 10 mg/(kg.d), pioglitazone 5 mg/(kg.d) plus TLR4-specific antagonist Eritoran 5 mg/(kg.d)...