版权说明 操作指南
首页 > 成果 > 详情

Design, synthesis and biological evaluation of 3 ',4 ',5 '-trimethoxy flavonoid benzimidazole derivatives as potential anti-tumor agents

认领
导出
下载 Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Wang, Zhe;Deng, Xiangping;Xiong, Runde;Xiong, Shujuan;Liu, Juan;...
通讯作者:
Zheng, Xing;Tang, Guotao
作者机构:
[Wang, Zhe; Deng, Xiangping; Liu, Juan; Lei, Xiaoyong; Xiong, Shujuan; Zheng, Xing; Tang, Guotao; Xiong, Runde; Cao, Xuan] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.
[Chen, Yanming] Mu Dan Jiang You Bo Pharmaceut Co Ltd, Mudanjiang, Peoples R China.
通讯机构:
[Zheng, X; Tang, GT] U
Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.
语种:
英文
期刊:
RSC Medicinal Chemistry
ISSN:
2632-8682
年:
2018
卷:
9
期:
2
页码:
305-315
基金类别:
Construct Program of the Key Discipline in Hunan province; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
A series of 3′,4′,5′-trimethoxy flavonoids with benzimidazole linked by different chain alkanes have been designed and synthesized. The potential activity of these compounds as anti-tumor agents was evaluated by cytotoxicity assay in MGC-803 (human gastric cancer), MCF-7 (human breast cancer), HepG-2 (human hepatoma) and MFC (mouse gastric cancer) tumor cell lines. Among them, compound 15 7-(3-(2-chloro-1H-benzo[d]imidazol-1-yl)propoxy)-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one displayed the most potent antiproliferative activity, with IC5...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com