[Wang, Zhe; Deng, Xiangping; Liu, Juan; Lei, Xiaoyong; Xiong, Shujuan; Zheng, Xing; Tang, Guotao; Xiong, Runde; Cao, Xuan] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

[Chen, Yanming] Mu Dan Jiang You Bo Pharmaceut Co Ltd, Mudanjiang, Peoples R China.

[Zheng, X; Tang, GT] U

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

3',4',5' trimethoxy flavonoid benzimidazole derivative;7 (2 bromoethoxy) 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 (3 bromopropoxy) 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 (4 bromobutoxy) 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 hydroxy 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [2 [1h benz[d]imidazol 1 yl]ethoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [2 [2 chloro 1h benz[d]imidazol 1 yl]ethoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [2 [2 methyl 1h benz[d]imidazol 1 yl]ethoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [2 [2 [trifluoromethyl] 1h benz[d]imidazol 1 yl]ethoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [2 [5 methoxy 1h benz[d]imidazol 1 yl]ethoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [2 [5 methyl 1h benz[d]imidazol 1 yl]ethoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [2 [5,6 dimethyl 1h benz[d]imidazol 1 yl]ethoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [2 [6 nitro 1h benz[d]imidazol 1 yl]ethoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [3 (2 chloro 1h benz[d]imidazol 1 yl)propoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [3 [1h benz[d]imidazol 1 yl]propoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [3 [2 chloro 1h benz[d]imidazol 1 yl]propoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [3 [2 methyl 1h benz[d]imidazol 1 yl]propoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [3 [2 [trifluoromethyl] 1h benz[d]imidazol 1 yl]propoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [3 [5 methoxy 1h benz[d]imidazol 1 yl]propoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [3 [5 methyl 1h benz[d]imidazol 1 yl]propoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [3 [5,6 dimethyl 1h benz[d]imidazol 1 yl]propoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [3 [6 nitro 1h benz[d]imidazol 1 yl]propoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [4 [1h benz[d]imidazol 1 yl]butoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [4 [2 chloro 1h benz[d]imidazol 1 yl]butoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [4 [2 methyl 1h benz[d]imidazol 1 yl]butoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;7 [4 [5 nitro 1h benz[d]imidazol 1 yl]butoxy] 2 (3,4,5 trimethoxyphenyl) 4h chromen 4 one;antineoplastic agent;benzimidazole derivative;flavonoid;fluorouracil;unclassified drug;unindexed drug;animal cell;antineoplastic activity;antiproliferative activity;apoptosis;Article;controlled study;cytotoxicity assay;drug design;drug synthesis;flow cytometry;G1 phase cell cycle checkpoint;human;human cell;IC50;in vitro study;in vivo study;mouse;nonhuman;priority journal;tumor growth

药学与生物科学学院