This work was supported in part by the Construct Program of the key Discipine in Hunan Province; the Hunan Province Cooperative Innovation Center for Molecular Target New Drug.
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
A series of chrysin benzimidazole derivatives were synthesised and evaluated for their anticancer activity in the search for potential anticancer agents. Among them, compound 18 displayed the most potent anti-proliferative activity against MFC cells with IC 50 values of 25.72±3.95μM. The flow cytometry results displayed that compound 18 induced apoptosis of MFC cells in a dose-dependent manner and caused the cell cycle to be arrested in the G0/G1 phase. Furthermore, the preliminary anticancer activity in vivo was also studied in tumour-bearin...