版权说明 操作指南
首页 > 成果 > 详情

Design, synthesis and biological evaluation of chrysin benzimidazole derivatives as potential anticancer agents

认领
导出
下载 Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Wang, Zhe;Deng, Xiangping;Xiong, Shujuan;Xiong, Runde;Liu, Juan;...
通讯作者:
Zheng, Xing;Tang, Guotao
作者机构:
[Wang, Zhe; Liu, Yunmei; Zou, Liu; Liu, Juan; Zheng, X; Tang, GT; Tang, Guotao; Zheng, Xing; Deng, Xiangping; Xie, Zhizhong; Lei, Xiaoyong; Xiong, Shujuan; Xiong, Runde; Cao, Xuan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang, Peoples R China.
[Chen, Yanming] Mu Dan Jiang You Bo Pharmacert Co Ltd, Mudanjiang, Peoples R China.
通讯机构:
[Zheng, X; Tang, GT] U
Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Inst Pharm & Pharmacol, Hengyang, Peoples R China.
语种:
英文
关键词:
antineoplastic agent;benzimidazole derivative;chrysin;compound 10;compound 11;compound 12;compound 13;compound 14;compound 15;compound 16;compound 17;compound 18;compound 19;compound 21;compound 22;compound 23;compound 3;compound 4;compound 5;compound 6;compound 7;compound 8;compound 9;fluorouracil;unclassified drug;antineoplastic agent;benzimidazole derivative;chrysin;flavonoid;animal experiment;animal model;antineoplastic activity;antiproliferative activity;apoptosis;Article;breast cancer;cancer inhibition;cell cycle arrest;cell cycle G0 phase;cell cycle G1 phase;controlled study;dose response;drug design;drug megadose;drug potency;drug screening;drug synthesis;Hep-G2 cell line;IC50;in vitro study;in vivo study;male;MCF-7 cell line;mouse;nonhuman;animal;cell cycle;cell proliferation;chemistry;drug effect;drug screening;human;synthesis;tumor cell line;xenograft;Animals;Antineoplastic Agents;Apoptosis;Benzimidazoles;Cell Cycle;Cell Line, Tumor;Cell Proliferation;Drug Design;Drug Screening Assays, Antitumor;Flavonoids;Heterografts;Humans;Mice
期刊:
Natural Product Research
ISSN:
1478-6419
年:
2018
卷:
32
期:
24
页码:
2900-2909
基金类别:
This work was supported in part by the Construct Program of the key Discipine in Hunan Province; the Hunan Province Cooperative Innovation Center for Molecular Target New Drug.
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
A series of chrysin benzimidazole derivatives were synthesised and evaluated for their anticancer activity in the search for potential anticancer agents. Among them, compound 18 displayed the most potent anti-proliferative activity against MFC cells with IC 50 values of 25.72±3.95μM. The flow cytometry results displayed that compound 18 induced apoptosis of MFC cells in a dose-dependent manner and caused the cell cycle to be arrested in the G0/G1 phase. Furthermore, the preliminary anticancer activity in vivo was also studied in tumour-bearin...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com