The formation mechanism and homeostasis of extrachromosomal DNA

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成果类型：

期刊论文

作者：

Tao, Yifang;Ning, Qian;Wang, Zewei;Tang, Nanyang;Zhao, Xuhong;...

通讯作者：

Shengsong Tang

作者机构：

[Tang, Shengsong; Tao, Yifang; Tang, Nanyang] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respone Dr, Hengyang 421001, Peoples R China.

[Tang, Shengsong; Tao, Yifang; Wang, Zewei; Tang, Nanyang] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Tang, Shengsong; Tao, Yifang; Wang, Zewei; Tang, Nanyang; Zhao, Xuhong; Ning, Qian] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Peoples R China.

[Tang, Shengsong] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

通讯机构：

[Shengsong Tang] H

Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, and Institute of Pharmacy and Pharmacology, University of South China , Hengyang421001 , China<&wdkj&>Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, School of Pharmaceutical Sciences, Hunan University of Medicine , Huaihua418000 , China<&wdkj&>College of Bioscience and Biotechnology, Hunan Agricultural University , Changsha 410128 , China

语种：

英文

期刊：

CARCINOGENESIS

ISSN：

0143-3334

年：

2022

卷：

期：

页码：

815-825

DOI：

10.1093/carcin/bgac072

基金类别：

Hunan Provincial Natural Science Foundation of China (2019JJ50416); Hunan Provincial Science and Technology Plan Key Projects of China (2017SK2183); the Scientific Research Project of Hunan Provincial Health Commission (202113022028).

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Extrachromosomal DNA, referred to as extrachromosomal DNA (ecDNA), was found in most cancers and nearly absent in normal cells. The properties of ecDNA enable tumor cells to be more responsive to various environments. The non-Mendelian genetic mechanism of ecDNA could arouse increasing tumor heterogeneity. Besides, ecDNA would promote tumor invasiveness and provide resistance mechanisms associated with poorer survival consequences. Furthermore, ecDNA could profoundly impact oncogene activation, genome instability, tumor heterogeneity, etc. Consequently, they may offer potential possibilities f...

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The formation mechanism and homeostasis of extrachromosomal DNA

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