Formaldehyde induces ferroptosis in hippocampal neuronal cells by upregulation of the Warburg effect

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成果类型：

期刊论文

作者：

Li, Xiao-Na;Yang, San-Qiao;Li, Min;Li, Xue-Song;Tian, Qing;...

通讯作者：

Wang, Chun-Yan;Tang, Xiao-Qing

作者机构：

[Li, Xiao-Na; Li, Xue-Song] Guangzhou Med Univ, Huizhou Peoples Hosp 3, Dept Neurosurg, Huizhou 516002, Guangdong, Peoples R China.

[Li, Min; Xiao, Fan; Wang, Chun-Yan; Tang, Yi-Yun; Tian, Qing; Tang, Xiao-Qing; Li, Xiao-Na; Wang, CY; Kang, Xuan] Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang 421001, Hunan, Peoples R China.

[Li, Min; Xiao, Fan; Zou, Wei; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

[Yang, San-Qiao; Tang, Xiao-Qing; Kang, Xuan] Univ South China, Affiliated Hosp 1, Inst Neurol, Hengyang 421001, Hunan, Peoples R China.

[Wang, Chun-Yan] Univ South China, Hengyang Med Coll, Dept Pathophysiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wang, CY; Tang, XQ] U

Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Ferroptosis;Formaldehyde;Neurotoxicity;Warburg effect

期刊：

Toxicology

ISSN：

0300-483X

年：

2021

卷：

448

页码：

152650

DOI：

10.1016/j.tox.2020.152650

基金类别：

This research was funded by National Natural Science Foundation of China (grant number 81771178), the Natural Science Foundation of Hunan Province (grant number 2019JJ80057, 2019JJ50556), and the Major Research Topics of the Health Commission of Hunan province ((grant number 20201911). CRediT authorship contribution statement Xiao-Na Li: Writing - original draft. San-Qiao Yang: Methodology. Min Li: Writing - original draft. Xue-Song Li: Data curation. Qing Tian: Writing - review & editing. Fan Xiao: acquisition. Yi-Yun Tang: Software. Xuan Kang: Visualization. Chun-Yan Wang: Writing - original draft, Writing - review & editing. Wei Zou: Data curation. Ping Zhang: Data curation. Xiao-Qing Tang: Conceptualization, Data curation, Writing - review & editing.

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

The mechanisms underlying formaldehyde (FA)-induced neurotoxicity have not yet been fully clarified. Ferroptosis is a novel regulatory cell death and the Warburg effect is involved in regulating neural function. In this study, we investigated whether FA-induced neurotoxicity is implicated in neuronal ferroptosis and determined whether the Warburg effect mediates FA-induced neuronal ferroptosis. We found that FA (0.1, 0.5 and 1.0 mM, 6 h) induced cell death in HT22 cells (a cell line of mouse hippocampal neuron), as evidenced by a decrease in ce...

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Formaldehyde induces ferroptosis in hippocampal neuronal cells by upregulation of the Warburg effect

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