Interferon-stimulated gene 15 promotes cholesterol efflux by activating autophagy via the miR-17-5p/Beclin-1 pathway in THP-1 macrophage-derived foam cells

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成果类型：

期刊论文

作者：

Huang, Chong;Yu, Xiao-Hua;Zheng, Xi-Long;Ou, Xiang*;Tang, Chao-Ke*

通讯作者：

Tang, Chao-Ke;Ou, Xiang

作者机构：

[Tang, Chao-Ke; Yu, Xiao-Hua; Huang, Chong] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis,Med Res Expt Ctr, Hengyang 421001, Hunan, Peoples R China.

[Ou, Xiang] First Hosp Changsha, Dept Endocrinol, Changsha 410005, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Cumming Sch Med,Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Tang, Chao-Ke] U

[Ou, Xiang] F

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis,Med Res Expt Ctr, Hengyang 421001, Hunan, Peoples R China.

First Hosp Changsha, Dept Endocrinol, Changsha 410005, Hunan, Peoples R China.

语种：

英文

关键词：

Autophagy;Beclin-1;Cholesterol efflux;ISG15;miR-17-5p

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2018

卷：

827

期：

页码：

13-21

DOI：

10.1016/j.ejphar.2018.02.042

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (81570408), Natural Science Fund Project in Hunan Province (2017JJ2286), Changsha Science and Technology Plan Project (KQ1602028) and the construct program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China, Xiangjiaofa No. [2011]76).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Macrophage autophagy contributes to the hydrolysis of cholesteryl ester into free cholesterol mainly for ATP-binding cassette transporter A1 (ABCA1)-dependent efflux. Interferon-stimulated gene 15 (ISG15) has been shown to regulate autophagy in multiple types of cells. The present study aimed to examine the effects of ISG15 on autophagy and cholesterol efflux in THP-1 macrophage-derived foam cells and to explore the underlying molecular mechanisms. Our results showed that overexpression of ISG15 promoted autophagy and cholesterol efflux and inhibited lipid accumulation without impact on ABCA1 ...

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Interferon-stimulated gene 15 promotes cholesterol efflux by activating autophagy via the miR-17-5p/Beclin-1 pathway in THP-1 macrophage-derived foam cells

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