ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1

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成果类型：

期刊论文

作者：

Li, Yu-kun;Gao, An-bo;Zeng, Tian;Liu, Dan;Zhang, Qun-feng;...

通讯作者：

Zhang, Juan;Li, Hui;Zou, J

作者机构：

[Li, Yu-kun; Gao, An-bo; Zou, Wen-da; Li, Hui; Zou, Juan; Zou, J; Peng, Juan; Zeng, Tian; Liu, Dan; Zhang, Juan; Li, Yan; Zhang, J] Cent South Univ, Xiangya Hosp Zhuzhou, Zhuzhou Cent Hosp, Dept Assisted Reprod Ctr, Zhuzhou, Hunan, Peoples R China.

[Zhang, Ting; Li, Yu-kun; Liu, Jue; Zou, Juan; Shi, Gang-qing; Zou, J; Zeng, Tian; Zhou, Wen-chao; Zhang, Qun-feng] Univ South China, Canc Res Inst, Hengyang Med Sch, Affiliated Hosp 2,Dept Gynecol,Hunan Prov Key Lab, Hengyang, Hunan, Peoples R China.

[Gao, An-bo] Univ South China, Affiliated Hosp 2, Clin Res Inst, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

[Ran, Xiao-min; Tang, Zhen-zi] Cent South Univ, Hunan Canc Hosp, Affiliated Canc Hosp Xiangya, Dept Gynecol Oncol,Sch Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Li, H; Zou, J ; Zhang, J] C

Cent South Univ, Xiangya Hosp Zhuzhou, Zhuzhou Cent Hosp, Dept Assisted Reprod Ctr, Zhuzhou, Hunan, Peoples R China.

Univ South China, Canc Res Inst, Hengyang Med Sch, Affiliated Hosp 2,Dept Gynecol,Hunan Prov Key Lab, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Ovarian cancer;ANGPTL4;ESM1;Angiogenesis;JAK2/STAT3 pathway

期刊：

Journal of Translational Medicine

ISSN：

1479-5876

年：

2024

卷：

期：

页码：

1-20

DOI：

10.1186/s12967-023-04819-8

基金类别：

The present study was supported by the Natural Science Foundation of HuNan Province (2021JJ50070 and 2023JJ41066).

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

BACKGROUND: Ovarian cancer (OC) is a malignant neoplasm that displays increased vascularization. Angiopoietin-like 4 (ANGPTL4) is a secreted glycoprotein that functions as a regulator of cell metabolism and angiogenesis and plays a critical role in tumorigenesis. However, the precise role of ANGPTL4 in the OC microenvironment, particularly its involvement in angiogenesis, has not been fully elucidated. METHODS: The expression of ANGPTL4 was confirmed by bioinformatics and IHC in OC. The potential molecular mechanism of ANGPTL4 was measured by RNA-sequence. We used a series of molecular biologi...

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ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1

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