Deep learning for hepatocellular carcinoma recurrence before and after liver transplantation: a multicenter cohort study

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成果类型：

期刊论文

作者：

Cao, Shuang;Yu, Sihan;Huang, Liangbin;Seery, Samuel;Xia, Yu;...

通讯作者：

Zhu, ZJ;Li, T;He, Q;Wang, L

作者机构：

[Zhu, Zhijun; Zhou, Guangpeng; Wei, Lin; Sun, Liying; Cao, Shuang; Zhang, Haiming] Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, State Key Lab Digest Hlth,Liver Transplantat Ctr,C, 95 Yongan Rd, Beijing 100050, Peoples R China.

[Yu, Sihan] Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol,Cardiol Dept, Beijing 100730, Peoples R China.

[Huang, Liangbin] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Breast & Thyroid Surg, Changsha 410028, Hunan, Peoples R China.

[Seery, Samuel] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Humanities & Social Sci, Beijing 100730, Peoples R China.

[Seery, Samuel] Newcastle Univ, Sch Pharm, NEWCASTLE UPON TYNE NE1 4LP, England.

通讯机构：

[He, Q ; Zhu, ZJ ; Li, T ; Wang, L ] C

Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, State Key Lab Digest Hlth,Liver Transplantat Ctr,C, 95 Yongan Rd, Beijing 100050, Peoples R China.

Cent South Univ, Xiang Ya Hosp 2, Dept Liver Transplantat, Changsha 410011, Peoples R China.

Capital Med Univ, Beijing Chaoyang Hosp, Med Res Ctr, Beijing Organ Transplant Ctr,Dept Hepatobiliary &, Beijing 100020, Peoples R China.

Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp, Beijing 100026, Peoples R China.

语种：

英文

关键词：

Hepatocellular carcinoma;Liver transplantation;Recurrence predictive models;Deep learning;DeepSurv

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2025

卷：

期：

页码：

7730

DOI：

10.1038/s41598-025-91728-z

基金类别：

This study was supported by Beijing Postdoctoral Research Foundation, and Tongzhou District Science and Technology Innovation Talent Support Project (CXTD2024007).

机构署名：

本校为其他机构

摘要：

Hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) is a major contributor to mortality. We developed a recurrence prediction system for HCC patients before and after LT. Data from patients with HCC who underwent LT were retrospectively collected from three specialist centres in China. Pre- and post-operative variables were selected using support vector machine, random forest, and logistic regression (LR). Then, pre- and post-operative models were developed using three machine learning methods: LR, stacking, and two survi...

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Deep learning for hepatocellular carcinoma recurrence before and after liver transplantation: a multicenter cohort study

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