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Deep learning for hepatocellular carcinoma recurrence before and after liver transplantation: a multicenter cohort study

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成果类型:
期刊论文
作者:
Cao, Shuang;Yu, Sihan;Huang, Liangbin;Seery, Samuel;Xia, Yu;...
通讯作者:
Lei Wang<&wdkj&>Ting Li<&wdkj&>Qiang He<&wdkj&>Zhijun Zhu
作者机构:
[Zhou, Guangpeng; Wei, Lin; Sun, Liying; Cao, Shuang; Zhang, Haiming] Liver Transplantation Center, Clinical Research Center for Pediatric Liver Transplantation, State Key Lab of Digestive Health, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, 95 Yong'an Road, Xicheng District, Beijing, 100050, China
[Yu, Sihan] Cardiology Department, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China
[Huang, Liangbin] Department of Breast and Thyroid Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410028, Hunan, China
[Seery, Samuel] Department of Humanities and Social Sciences, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China
[Seery, Samuel] School of Pharmacy, Newcastle University, Newcastle, NE1 4LP, UK
通讯机构:
[Lei Wang] B
[Ting Li; Qiang He] D
[Zhijun Zhu] L
Liver Transplantation Center, Clinical Research Center for Pediatric Liver Transplantation, State Key Lab of Digestive Health, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China<&wdkj&>Department of Hepatobiliary and Pancreaticosplenic Surgery, Medical Research Center, Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China<&wdkj&>Department of Liver Transplantation, The Second Xiang-ya Hospital, Central South University, Changsha, China<&wdkj&>Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China
语种:
英文
关键词:
Deep learning;DeepSurv;Hepatocellular carcinoma;Liver transplantation;Recurrence predictive models
期刊:
Scientific Reports
ISSN:
2045-2322
年:
2025
卷:
15
期:
1
页码:
7730
基金类别:
This study was supported by Beijing Postdoctoral Research Foundation, and Tongzhou District Science and Technology Innovation Talent Support Project (CXTD2024007).
机构署名:
本校为其他机构
摘要:
Hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) is a major contributor to mortality. We developed a recurrence prediction system for HCC patients before and after LT. Data from patients with HCC who underwent LT were retrospectively collected from three specialist centres in China. Pre- and post-operative variables were selected using support vector machine, random forest, and logistic regression (LR). Then, pre- and post-operative models were developed using three machine learning methods: LR, stacking, and two survi...

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