Cytokine IL-5 and HGF: combined prediction of non-/low immune response to hepatitis B vaccination at birth in infants born to HBsAg-positive mothers

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成果类型：

期刊论文

作者：

Ou, Guanyong;Qing, Ling;Zhang, Li;Yang, Yang;Ye, Guoguo;...

通讯作者：

Liu, YX

作者机构：

[Ye, Guoguo; Liu, Yingxia; Li, Yanjie; Qing, Ling; Zhang, Li; Yang, Liuqing; Ou, Guanyong; Peng, Ling; Yang, Yang] Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, State Key Discipline Infect Dis,Hosp 2, Shenzhen, Peoples R China.

[Ou, Guanyong] Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China.

[Qing, Ling; Zhang, Li] Univ South China, Grad Collaborat Training Base, Hengyang Med Sch, Shenzhen Peoples Hosp 3, Hengyang, Peoples R China.

通讯机构：

[Liu, YX ] S

Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, State Key Discipline Infect Dis,Hosp 2, Shenzhen, Peoples R China.

语种：

英文

关键词：

hepatitis B vaccine;HGF;IL-5;cytokine;immune response;infant;non/low response

期刊：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ISSN：

2235-2988

年：

2024

卷：

页码：

1332666

DOI：

10.3389/fcimb.2024.1332666

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The present study was supported by the National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment” (grant number 2017ZX10201201-005-001, 2017ZX10201201-001-007, 2017ZX10201201-002-007); Hospital level project of Shenzhen Third People’s Hospital (grant number G2022146, 24250G1011); National Natural Science Foundation of China (grant number 81873573).

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摘要：

BACKGROUND: The immune response to hepatitis B vaccine may be influenced by numerous factors, and patients with non/low response re-exposed to hepatitis B virus remain susceptible. Thus, a better understanding of the underlying mechanisms of non/low immune response in infants born to Hepatitis B surface antigen (HBsAg)-positive mothers is essential. METHODS: 100 infants born to HBsAg-positive mothers from 2015 to 2020 were enrolled in the study, further divided into the non/low response group (n=13) and the moderate strong response group (n=87) based on the quantification of hepatitis B surfac...

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Cytokine IL-5 and HGF: combined prediction of non-/low immune response to hepatitis B vaccination at birth in infants born to HBsAg-positive mothers

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