The effects of doxorubicin loaded aptamer S3-linked DNA tetrahedrons on nasopharyngeal carcinoma

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成果类型：

期刊论文

作者：

Liu, Xiwu;Jiang, Bincan;Cheng, Ailan;Guo, Youwei;Wang, Lei;...

通讯作者：

Jiang, Xingjun;Ren, CP;Jiang, XJ

作者机构：

[Liu, Weidong; Ren, CP; Li, Yihan; Guo, Youwei; Yin, Wen; Ren, Caiping; Jiang, Xingjun; Wang, Lei; Liu, Xiwu] Cent South Univ, Xiangya Hosp, NHC Key Lab Carcinogenesis, Changsha 410008, Hunan, Peoples R China.

[Ren, CP; Guo, Youwei; Yin, Wen; Ren, Caiping; Jiang, Xingjun] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

[Jiang, Bincan; Cheng, Ailan] Univ South China, Hengyang Med Sch, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Liu, Weidong; Ren, CP; Li, Yihan; Ren, Caiping; Wang, Lei; Liu, Xiwu] Cent South Univ, Canc Res Inst, Sch Basic Med Sci, Changsha 410078, Hunan, Peoples R China.

[Guo, Youwei; Yin, Wen; Jiang, Xingjun] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Ren, CP ; Jiang, XJ; Jiang, XJ ] C

Cent South Univ, Xiangya Hosp, NHC Key Lab Carcinogenesis, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Canc Res Inst, Sch Basic Med Sci, Changsha 410078, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Nasopharyngeal carcinoma;Aptamer S3;CD109;5-8F cells;DNA tetrahedrons;Doxorubicin

期刊：

Journal of Otolaryngology - Head & Neck Surgery

ISSN：

1916-0216

年：

2023

卷：

期：

页码：

1-13

DOI：

10.1186/s40463-023-00673-2

基金类别：

This study was supported by the National Natural Science Foundation of China (No. 81773179), Key R & D Program of Hunan Province (No. 2022SK2055), Natural Science Foundation of Hunan Province (No. 2020JJ4771) and National Undergraduate Training Program for Innovation and Entrepreneurship, University of South China (No. 202210555070).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Our research group in the early stage identified CD109 as the target of aptamer S3 in nasopharyngeal carcinoma (NPC). This study was to use S3 to connect DNA tetrahedron (DT) and load doxorubicin (Dox) onto DT to develop a targeted delivery system, and explore whether S3-DT-Dox can achieve targeted therapy for NPC. Aptamer S3-conjugated DT was synthesized and loaded with Dox. The effects of S3-DT-Dox on NPC cells were investigated with laser confocal microscopy, flow cytometry, and MTS assays. A nude mouse tumor model was established from NPC 5...

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The effects of doxorubicin loaded aptamer S3-linked DNA tetrahedrons on nasopharyngeal carcinoma

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