Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Jinna;Zhang, Jianwu;Wu, Jiaxiong;Zhang, Shulei;Liang, Yamin;...

通讯作者：

Wu, Peng;Wei, Dangheng

作者机构：

[Zhou, Bin; Chen, Jinna; Zhang, Shulei; Liang, Yamin; Wu, Peng; Wu, Jiaxiong; Wei, Dangheng] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hunan Int Sci & Technol Cooperat Base Arterioscle, Hengyang 421001, Hunan, Peoples R China.

[Chen, Jinna] Hunan Univ Med, Dept Pathol & Pathophysiol, Huaihua 418000, Hunan, Peoples R China.

[Zhang, Jianwu] Hunan Univ Med, Affiliated Hosp 1, Dept Emergency, Huaihua 418000, Hunan, Peoples R China.

[Wu, Peng; Wei, Dangheng] Univ South China, Hengyang 42001, Peoples R China.

通讯机构：

[Wu, P; Wei, DH] U

Univ South China, Hengyang 42001, Peoples R China.

语种：

英文

关键词：

Low shear stress;Mitochondrial injury;Pyroptosis;Reactive oxygen species;Succinate dehydrogenase B;Ten-Eleven Translocation 2;Vascular endothelial cell

期刊：

Free Radical Biology and Medicine

ISSN：

0891-5849

年：

2021

卷：

162

期：

页码：

582-591

DOI：

10.1016/j.freeradbiomed.2020.11.017

基金类别：

This work was supported by the grants from the National Natural Science Foundation of China (No. 31670962 , 81370378 ), Scientific Research Fund Project of Hunan Provincial Health Commission ( 20200011–1003 ), the Research project of graduate students in University of South China ( 2018XJXZ374 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Vascular endothelial cell (VEC) inflammation induced by low shear stress plays key roles in the initiation and progression of atherosclerosis (As). Pyroptosis is a form of inflammatory programmed cell death that is critical for As. However, the effect of low shear stress on VEC pyroptosis and the underlying mechanisms were not clear. Here we show that low shear stress promoted VEC pyroptosis and reduced the expression of Ten-Eleven Translocation 2 (TET2) methylcytosine dioxygenase. Loss of TET2 resulted in the upregulation of the expression and activity of mitochondrial respiratory complex II ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问