Nicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis

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成果类型：

期刊论文

作者：

Lin, Xiu-lian;Zeng, Ya-ling;Ning, Jie;Cao, Zhe;Bu, Lan-lan;...

通讯作者：

Liao, Duan-fang;Li, Ya-Mei;Zeng, JG;Liao, DF

作者机构：

[Fu, Rong-geng; Zhang, Zhi-min; Lin, Xiu-lian; Zeng, Jian-Guo; Li, Ya-Mei; Bu, Lan-lan; Liao, Wen-Jing; Lin, Li-Mei; Liao, Duan-fang; Cao, De-liang; Gong, Yong-zhen; Zeng, Ya-ling; Zhao, Tan-jun; Ning, Jie; Liao, DF] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.

[Cao, Zhe; Cao, De-liang] Hunan Laituofu Biotechnol Co Ltd, Ningxiang 410604, Hunan, Peoples R China.

[Yang, Xue-Feng; Liao, DF; Liao, Duan-fang] Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang 421002, Hunan, Peoples R China.

[Zeng, Jian-Guo] Hunan Agr Univ, Hunan Key Lab Tradit Chinese Vet Med, Changsha 410128, Hunan, Peoples R China.

[Zhang, Cai-ping] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Liao, DF ; Li, YM; Zeng, JG ; Liao, DF] H

Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.

Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Hengyang 421002, Hunan, Peoples R China.

Hunan Agr Univ, Hunan Key Lab Tradit Chinese Vet Med, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Nicotinate-Curcumin;NASH;AKR1B10;Triglyceride

期刊：

Lipids in Health and Disease

ISSN：

1476-511X

年：

2024

卷：

期：

页码：

1-16

DOI：

10.1186/s12944-024-02162-5

基金类别：

This work was supported by Hunan Changzhutan national independent innovation zone special project (No.2018XK2106); Hunan Science and Technology Innovation Team Project (No.2021RC4064) and Key Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine (No.202302); Outstanding Youth Program of Hunan Provincial Department of Education (No.21B0397); Natural Science Foundation of Hunan University of Chinese Medicine (NO. Z2023XJYB12).

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying mechanism of nicotinate-curcumin (NC) in the treatment of NASH remain uncertain. A rat model of NASH induced by a high-fat and high-fructose diet was treated with nicotinate-curcumin (NC, 20, 40 mg·kg− 1), curcumin (Cur, 40 mg·kg− 1) and metformin (Met, 50 mg·kg− 1) for a duration of 4 weeks. The interaction between NASH, Cur and Aldo-Keto reductase family 1 member B10 (AKR1B10) was filter and analyzed ...

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Nicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis

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