PARP1 modulates METTL3 promoter chromatin accessibility and associated LPAR5 RNA m6A methylation to control cancer cell radiosensitivity

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成果类型：

期刊论文

作者：

Sun, Xiaoya;Bai, Chenjun;Li, Haozheng;Xie, Dafei;Chen, Shi;...

通讯作者：

Gao, Shanshan;Zhou, PK;Huang, RX

作者机构：

[Li, Haozheng; Long, Dingxin; Chen, Shi; Sun, Xiaoya; Jia, Jin; Zhou, Ping-Kun] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Luo, Jinhua; Zhou, Ping-Kun; Xie, Dafei; Han, Yang; Bai, Chenjun; Li, Haozheng; Huang, Xin; Guan, Hua; Gao, Shanshan; Chen, Shi; Sun, Xiaoya; Jia, Jin] Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Luo, Jinhua; Huang, RX; Huang, Ruixue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

[Ye, Yumeng; Li, Yang] Beijing Inst Radiat Med, Dept Expt Pathol, Beijing 100850, Peoples R China.

通讯机构：

[Zhou, PK ; Gao, SS] B

[Huang, RX ] C

Beijing Inst Radiat Med, Dept Radiat Biol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Hunan, Peoples R China.

语种：

英文

关键词：

DNA damage response;PARP1;chromatin accessibility;m(6)A methylation;radiosensitivity

期刊：

Molecular Therapy

ISSN：

1525-0016

年：

2023

卷：

期：

页码：

2633-2650

DOI：

10.1016/j.ymthe.2023.07.018

基金类别：

National Natural Sci-ence Foundation of China [82230108, 82103784, 32171238]

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

Chromatin remodeling and N(6)-methyladenosine (m(6)A) modification are two critical layers in controlling gene expressionand DNA damage signaling in most eukaryotic bioprocesses. Here, we report that poly(ADP-ribose) polymerase 1 (PARP1) controls the chromatin accessibility of METTL3 to regulate its transcription and subsequent m(6)A methylation of poly(A)(+) RNA in response to DNA damage induced by radiation. The transcription factors nuclear factor I-C (NFIC) and TATA binding protein (TBP) are dependent on PARP1 to access the METTL3 promoter to activate METTL3 transcription. Upon irradiation...

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PARP1 modulates METTL3 promoter chromatin accessibility and associated LPAR5 RNA m6A methylation to control cancer cell radiosensitivity

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