Endocan: A Key Player of Cardiovascular Disease

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Jinzhi;Jiang, Liping;Yu, Xiao-Hua;Hu, Mi;Zhang, Yang-Kai;...

通讯作者：

Ouyang, XP;He, PP

作者机构：

[Ouyang, Xinping; Chen, Jinzhi; Liu, Xin; Jiang, Liping; Hu, Mi] Univ South China, Hengyang Med Coll, Basic Med Sch, Neurosci Inst,Dept Physiol,Hengyang Key Lab Neuro, Hengyang, Peoples R China.

[Jiang, Liping] Hunan Taihe Hosp, Clin Drug Res Ctr, Changsha, Peoples R China.

[Yu, Xiao-Hua] Hainan Med Univ, Affiliated Hosp 2, Inst Clin Med, Haikou, Peoples R China.

[Zhang, Yang-Kai] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Hengyang, Peoples R China.

[He, Pingping] Univ South China, Hengyang Med Coll, Sch Nursing, Hengyang, Peoples R China.

通讯机构：

[Ouyang, XP ; He, PP ] U

Univ South China, Hengyang Med Coll, Basic Med Sch, Neurosci Inst,Dept Physiol,Hengyang Key Lab Neuro, Hengyang, Peoples R China.

Univ South China, Hengyang Med Coll, Sch Nursing, Hengyang, Peoples R China.

语种：

英文

关键词：

Endocan;Atherosclerosis;Inflammation;endothelial dysfunction;cvd

期刊：

FRONTIERS IN CARDIOVASCULAR MEDICINE

ISSN：

2297-055X

年：

2022

卷：

页码：

798699

DOI：

10.3389/fcvm.2021.798699

基金类别：

The authors gratefully acknowledge the financial supports from the Natural Science Foundation of China (No. 82170485), the Natural Science Foundation of Hunan Province, China (Grant No. 2019JJ40249), Key Project of Hunnan Provincial Department of Education (20A427), The Ministry of Education Industry-University Cooperation Collaborative Education Project (202002138007), and Hunan Provincial Innovation Foundation For Postgraduate (CX20200960).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

护理学院

摘要：

Endothelial dysfunction is considered to be an early change in atherosclerosis. Endocan, also known as endothelial cell specific molecule-1, is a soluble proteoglycan mainly secreted by endothelial cells. Inflammatory factors such as IL-1β and TNF-α can up regulate the expression of endocan and then affect the expression of cell adhesion molecules, such as ICAM-1 and VCAM-1, which play an important role in promoting leukocyte migration and inflammatory response. Elevated plasma levels of endocan may reflect endothelial activation and dysfunct...

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