期刊论文

Yu, XD;Yin, XH;Xiao, ZY

英文

Physiology & Behavior

0031-9384

2024

277

114461

10.1016/j.physbeh.2024.114461

The project was supported by Department of Education, Hunan Province, China (20C1661 to H.L., 21A0474 to X.C.L.), Hunan Provincial Health Commission, China (202114050140 to K.S.Q.) and National College Students Innovation and Entrepreneurship Training Program (S202310547009 and S202310547041 to L.Y.). CRediT authorship contribution statement Huang Li: acquisition, Project administration. Lu Ying: acquisition, Project administration. Fu Wan: Data curation, Investigation, Visualization. Kang Shiqiao: acquisition, Software, Visualization. Fang Yijie: Data curation, Visualization. Xiao Chuli: acquisition, Investigation. Yu Xudong: Investigation, Writing – original draft, Writing – review & editing. Yin Xinhong: Investigation, Writing – original draft. Xiao Zhiyong: Investigation, Writing – original

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Esketamine, the right-handed optical isomer of racemic ketamine, is a rapidly acting antidepressant approved by the FDA for treatment-resistant depression in 2019. However, few studies have investigated esketamine's role in learning and memory, particularly in the context of memory reconsolidation. Herein, we evaluated esketamine's role in memory reconsolidation in 7-week-old male Institute of Cancer Research mice subjected to the novel object recognition (NOR) memory task. The NOR reconsolidation procedure comprised three phases: sampling, rea...