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The roles of FHL2 in cancer

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成果类型:
期刊论文
作者:
Zhang, Jiawei;Zeng, Qun;She, Meihua
通讯作者:
She, MH
作者机构:
[Zeng, Qun; Zhang, Jiawei; She, Meihua; She, MH] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Changsheng West Rd 28, Hengyang 421001, Peoples R China.
通讯机构:
[She, MH ] U
Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Changsheng West Rd 28, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Four and a half LIM protein 2 (FHL2);LIM-only protein family;Tumor progression;Cancer treatment;Signaling pathways
期刊:
CLINICAL AND EXPERIMENTAL MEDICINE
ISSN:
1591-8890
年:
2023
卷:
23
期:
7
页码:
3113-3124
基金类别:
This study was supported by Excellent Youth Project of Hunan Provincial Education Department [Grant No.22B0411]; Hunan Provincial Innovation Foundation For Postgraduate [Grant No.CX20210960].
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
药学与生物科学学院
摘要:
LIM domain protein 2, also known as LIM protein FHL2, is a member of the LIM-only family. Due to its LIM domain protein characteristics, FHL2 is capable of interacting with various proteins and plays a crucial role in regulating gene expression, cell growth, and signal transduction in muscle and cardiac tissue. In recent years, mounting evidence has indicated that the FHLs protein family is closely associated with the development and occurrence of human tumors. On the one hand, FHL2 acts as a tumor suppressor by down-regulating in tumor tissue and effectively inhibiting tumor development by li...

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