Long non-coding RNA MIAT is estrogen-responsive and promotes estrogen-induced proliferation in ER-positive breast cancer cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Yuehua;Jiang, Baohong;Wu, Xiaoping*;Huang, Qin;Chen, Wenqi;...

通讯作者：

Wu, Xiaoping

作者机构：

[Qu, Xiaofei; Zhu, Hongbo; Li, Yuehua; Xie, Liming; Wu, Xiaoping] Univ South China, Affiliated Hosp 1, Dept Med Oncol, 69 Chuanshan Rd, Hengyang City 421001, Hunan, Peoples R China.

[Jiang, Baohong] Univ South China, Affiliated Hosp 1, Dept Pharm, Hengyang City 421001, Hunan, Peoples R China.

[Huang, Qin] Univ South China, Dept Histol & Embryol, Lab Reprod Med, Hengyang City, Hunan, Peoples R China.

[Chen, Wenqi] Univ Hong Kong, Shenzhen Hosp, Dept Oncol, Shenzhen 518000, Peoples R China.

[Ma, Xin] Univ South China, Affiliated Hosp 1, Dept Pathol, Hengyang City, Hunan, Peoples R China.

通讯机构：

[Wu, Xiaoping] U

Univ South China, Affiliated Hosp 1, Dept Med Oncol, 69 Chuanshan Rd, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Breast cancer;Cell cycle;Estrogen receptor;Long non-coding RNA;MIAT;Proliferation

期刊：

Biochemical and Biophysical Research Communications

ISSN：

0006-291X

年：

2018

卷：

503

期：

页码：

45-50

DOI：

10.1016/j.bbrc.2018.05.146

基金类别：

This work was supported by Hunan Provincial Natural Science Foundation of China (Project number: 2015JJ2119 and 2018JJ6092).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Estrogen drives the development and progression of estrogen receptor (ER)-positive breast cancer. However, the detailed mechanism underlying ER-driven carcinogenesis remains unclear despite extensive studies. Previously reports indicated higher expression of long non-coding RNA (lncRNA) myocardial infarction associated transcript (MIAT) in ER-positive breast cancer tissues than in ER-negative tissues. However, the functional relevance of MIAT in ER-positive breast cancer tumorigenesis was poorly understood. Here, we investigated the role of lnc...

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Long non-coding RNA MIAT is estrogen-responsive and promotes estrogen-induced proliferation in ER-positive breast cancer cells

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