期刊论文

Zhou PingKun

英文

科学通报(英文版)

2095-9273

2011

56

30

3162-3171

10.1007/s11434-011-4702-x

We thank Dr. Andrew S. Belmont for kindly providing the AO3_1 CHO cell line, and Dr. lan N Hampson （University of Manchester Gynaecological Oncology Labs, School of Cancer ＆ Enabling Sciences） for kindly providing the C33A-E6 and C33A-C cells. This work was supported by the National Basic Research Program of China （2007CB914603）, the National Natural Science Foundation of China （30970677）, and the Outstanding Youth Scientist Foundation of National Natural Science Foundation of China （30825011）.

本校为其他机构

PIG3 (p53-inducible gene 3), originally identified as one of a set of genes induced by p53 before the onset of apoptosis, was assumed to contribute to early cellular response to DNA damage. Here, we studied the relation between p53 status and the increased expression of PIG3 by ionizing radiation (IR), and the related clues regarding the involvement of PIG3 in the cellular response to IR-induced DNA damage signaling. We demonstrated that the pentanucleotide microsatellite sequence was responsible for the p53-dependent induction of PIG3 transcri...

PIG3 (p53 可诱导的基因 3 ) ，原来作为 p53 在 apoptosis 的发作前导致的一套基因之一识别了，被假定贡献早细胞的反应到 DNA 损坏。这里，我们由电离学习了在 p53 地位和 PIG3 的增加的表示之间的关系放射(红外) ，和关于在对导致红外的 DNA 的细胞的反应的 PIG3 的参与的相关线索损坏发信号。我们证明 pentanucleotide microsatellite 顺序为在照耀以后的 PIG3 抄写的 p53 依赖的正式就职负责，当 PIG3 倡导者在上游的顺序能维持不由照耀可诱导的表示的基础水平时。PIG3 和 KRAB-ZFP-associated 的相互作用蛋白质 1 (KAP1 ) ， DNA 损坏反应蛋白质，被揭示。PIG3 原子核 foci 被形成在光线照...