In this study, amino modified mesoporous silica (HMS-TEEPA-TEA) was used for the first time to remove uranium (VI) from aqueous solution. The synthesized HMS-TEEPA-TEA was characterized by SEM, EDS, FTIR, BET and XPS techniques. The present work attempted to optimize and compare the adsorption process parameters like pH, adsorbate concentration, and adsorbent dose using Box-Behnken designs of response surface methodology. The adsorption amount and removal rate reached 337.26 mg/g and 99.57%, respectively. Model P> F F