A primary study on genes with selected mutations by in vitro passage of Chlamydia muridarum strains

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhou, Zhou;Liu, Na;Wang, Yingzi;Emmanuel, Arthur Wirekoh;You, Xiaoxing;...

通讯作者：

Wu, Yimou

作者机构：

[Li, Zhongyu; Zhou, Zhou; Wu, Yimou; Liu, Na; You, Xiaoxing; Wang, Yingzi; Zhong, Guangming; Emmanuel, Arthur Wirekoh] Univ South China, Coll Med, Inst Pathogen Biol, Hengyang 421001, Hunan, Peoples R China.

[Li, Zhongyu; Zhou, Zhou; Wu, Yimou; Liu, Na; You, Xiaoxing; Wang, Yingzi; Emmanuel, Arthur Wirekoh] Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

[Liu, Jiulin] Univ South China, Coll Med, Outstanding Phys Class Grade 2016, Hengyang 421001, Hunan, Peoples R China.

[Zhong, Guangming] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA.

[Wu, Yimou] Univ South China, Pathogen Biol Inst, 28 Changsheng Western Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Pathogen Biol Inst, 28 Changsheng Western Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Chlamydia muridarum (C. muridarum);biological characteristics;pathogenic mechanism;urogenital infection

期刊：

Pathogens and Disease

ISSN：

2049-632X

年：

2019

卷：

期：

页码：

DOI：

10.1093/femspd/ftz017

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31570179, 30901352]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]; Foundation of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control [2014-5]; Construct Program of the Key Discipline in Hunan Province [2011-76]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

OBJECTIVE: This study is to investigate the functions of newly discovered genes in Chlamydia muridarum (C. muridarum) strains with single gene differences. METHODS: Using whole genome sequencing and plaque formation assays, C. muridarum parental and passaging strains were established, and the isogenic clones expressing certain genotypes were isolated. Strains with single gene differences were obtained. Based on prediction, the valuable strains with single gene differences of tc0412, tc0668 or tc0237 were subjected to the in vitro and in vivo ex...

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A primary study on genes with selected mutations by in vitro passage of Chlamydia muridarum strains

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