Landscape and significance of human super enhancer-driven core transcription regulatory circuitry

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Feng, Chenchen;Song, Chao;Jiang, Yong;Zhao, Jun;Zhang, Jian;...

通讯作者：

Li, CQ

作者机构：

[Feng, Chenchen; Zhang, Jian; Wang, Yuezhu; Ai, Bo; Zhao, Jun; Li, Chunquan; Zhu, Jiang] Harbin Med Univ, Sch Med Informat, Daqing Campus, Daqing 163319, Peoples R China.

[Zhang, Yuexin; Wang, Qiuyu; Song, Chao; Yin, Mingxue; Shang, Desi; Liu, Jiaqi; Li, Chunquan; Qian, Fengcui] Univ South China, Affiliated Hosp 1, Inst Cardiovasc Dis, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuexin; Wang, Qiuyu; Song, Chao; Yin, Mingxue; Shang, Desi; Liu, Jiaqi; Li, Chunquan; Qian, Fengcui] Univ South China, Sch Comp, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuexin; Wang, Qiuyu; Song, Chao; Yin, Mingxue; Shang, Desi; Liu, Jiaqi; Li, Chunquan; Qian, Fengcui] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Cardiovasc Lab Big Data & Imaging Affiliated Intel, Hengyang 421001, Hunan, Peoples R China.

[Wang, Qiuyu; Shang, Desi; Li, Chunquan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Li, CQ ]

Harbin Med Univ, Sch Med Informat, Daqing Campus, Daqing 163319, Peoples R China.

语种：

英文

关键词：

prostate specific antigen;transcription factor;Article;biological functions;cancer immunotherapy;controlled study;core transcription regulatory circuitry;coronary artery tissue;disease marker;enhancer region;heart development;heart tissue;human;human cell;human tissue;KEGG;lipid metabolism;regulatory mechanism;self concept;sequence alignment;signal transduction;tissue specificity

期刊：

Molecular Therapy - Nucleic Acids

ISSN：

2162-2531

年：

2023

卷：

页码：

385-401

DOI：

10.1016/j.omtn.2023.03.014

基金类别：

This work was supported by the National Natural Science Foundation of China ( 62001145 , 62171166 , and 62272212 ), the Natural Science Foundation for Distinguished Young Scholars of Heilongjiang Province of China ( JQ2020C004 ), the Research Foundation of the First Affiliated Hospital of University of South China for Advanced Talents ( 20210002-1005 USCAT-2021-01 ), Wu Liande Youth Science Research Fund of Harbin Medical University (Daqing) ( JFWLD202001 ), and the China Postdoctoral Science Foundation ( 2019M661311 ).

机构署名：

本校为其他机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

A core transcription regulatory circuitry (CRC) is an interconnected self-regulatory circuitry that is formed by a group of core transcription factors (TFs). These core TFs collectively regulate gene expression by binding not only to their own super enhancers (SEs) but also to the SEs of one another. For most human tissue/cell types, a global view of CRCs and core TFs has not been generated. Here, we identified numerous CRCs using two identification methods and detailed the landscape of the CRCs driven by SEs in large cell/tissue samples. The c...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Landscape and significance of human super enhancer-driven core transcription regulatory circuitry

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问