期刊论文

中文

武汉体育学院学报

1000-520X

2014

48

04

97-100

10.3969/j.issn.1000-520X.2014.04.018

国家自然科学基金（81173060） 南华大学归国人员基金（2010XQD44）.

本校为第一机构

目的：探索游泳运动对大鼠胰岛Fractalkine （FKN）表达及PI3K/Akt信号通路影响，进一步阐明有氧运动改善糖尿病糖代谢的机制。方法：本研究以雄性成年SD大鼠为实验对象，利用高脂高糖饲料加腹腔注射链脲佐菌素（STZ ，30mg/kg）建立2型糖尿病胰岛素抵抗大鼠模型（T2DM ）。按一定时间对大鼠进行游泳训练。采用血清学检测试剂盒血清中胰岛素和血糖的含量，计算大鼠的胰岛素抵抗指数（HOMA-IR）。免疫印迹技术检测骨骼肌中葡萄糖转运蛋白4（ GLUT4）和胰岛中FKN 及PI3K/Akt信号蛋白的表达。结果：与正常大鼠相比，糖尿病大鼠血清胰岛素和空腹血糖水平显著增加，HO-MA -IR升高；腓肠肌 GLUT4和胰腺...

The objective of this study was to investigate the effect of exercise on the expressions of Fractalkine (FKN) and phosphatidylinositol 3 kinase (P13K0/protein kinase B (PKB ,Akt) signal pathway in the pancreas of Type 2 diabetic rats (T2DM ) .Adult male SD rats were used to develop the Type 2 diabetic models by the high fat and high-glucose diet ,in-traperitoneal injection of streptozotocin (STZ ,30 mg/kg) .The rats were trained in swimming by schedule procedures . Index of insulin resistance (HOMA-IR) was calculated respectively by values of serum insulin and fasting blood-glucose (FBG) deter...