Recombinant protein CPSIT_0846 induces protective immunity against Chlamydia psittaci infection in BALB/c mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ran, Ou;Liang, Mingxing;Yu, Jian;Yu, Minjun;Song, Ying;...

通讯作者：

Wu Yimou

作者机构：

[Wu Yimou; Yu, Minjun; Ran, Ou] Univ South China, Coll Med, Pathogen Biol Inst, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

[Wu Yimou; Ran, Ou] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Ran, Ou] Cent Hosp Xiangtan, Dept Clin Lab, Xiangtan 411100, Peoples R China.

[Liang, Mingxing] First Peoples Hosp Huaihua, Dept Clin Lab, Huaihua 418000, Peoples R China.

[Yu, Jian] Univ South China, Coll Med, Dept Expt Zool, Hengyang 421001, Peoples R China.

通讯机构：

[Wu Yimou] U

Univ South China, Coll Med, Pathogen Biol Inst, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Chlamydia psittaci;CPSIT_0846;mouse;immune response;protective efficacy

期刊：

Pathogens and Disease

ISSN：

2049-632X

年：

2017

卷：

期：

DOI：

10.1093/femspd/ftx018

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31270218]; Special Foundation of Hunan Provincial Science and Technology Department [2013TT1003]; construct program of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Chlamydia psittaci is an obligate intracellular bacteria that causes respiratory disease in poultry and humans. Currently, there are no licensed vaccines against chlamydial infection in humans. The transmembrane head protein CPSIT_0846 of C. psittaci is a putative member of the larger Inc protein family. In this study, we investigated immunogenicity and protective efficacy of the recombinant CPSIT_0846 protein in BALB/c mice. Mice immunized with CPSIT_0846 developed strong T-lymphocyte responses that were recalled by the immunogen CPSIT_0846 in...

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Recombinant protein CPSIT_0846 induces protective immunity against Chlamydia psittaci infection in BALB/c mice

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