Targeted proteomic analysis of 14-3-3σ in nasopharyngeal carcinoma

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成果类型：

期刊论文

作者：

Huang, Wei-Guo;Cheng, Ai-Lan;Chen, Zhu-Chu;Peng, Fang;Zhang, Peng-Fei;...

通讯作者：

Xiao, Zhi-Qiang

作者机构：

[Li, Cui; Li, Feng; Xiao, Zhi-Qiang; Cheng, Ai-Lan; Huang, Wei-Guo; Yi, Bin; Li, Jian-Ling; Yi, Hong; Li, Mao-Yu; Peng, Fang; Zhang, Peng-Fei; Li, Xin-Hui; Chen, Zhu-Chu] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Changsha 410008, Hunan, Peoples R China.

[Cheng, Ai-Lan; Huang, Wei-Guo] Univ S China, Canc Res Inst, Hengyang 421001, Peoples R China.

[Xiao, Zhi-Qiang] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Xiangya Rd 87, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Xiao, Zhi-Qiang] C

Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Canc Prote, Xiangya Rd 87, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Nasopharyngeal carcinoma;Protein-protein interaction;14-3-3 sigma;Targeted proteomics;Cellular biology

期刊：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ISSN：

1357-2725

年：

2010

卷：

期：

页码：

137-147

DOI：

10.1016/j.biocel.2009.10.001

基金类别：

National Key Basic Research Program of ChinaNational Basic Research Program of China [2001CB510207]; National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973290]; Ministry of Education of ChinaMinistry of Education, China [2002-48]; Lotus Scholars Program of Hunan Province, China [2007-362]; Science and Technology Committee of Hunan, China [04XK1001-1, 05SK1004-1]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

14-3-3 sigma is a potential tumor suppressor, and loss of 14-3-3 sigma expression plays an important role in carcinogenesis and metastasis. To explore the possible mechanism of 14-3-3 sigma in nasopharyngeal carcinoma (NPC) invasion and metastasis, targeted proteomic analysis was performed on 14-3-3 sigma-associated proteins from NPC cells. As the results, 112 proteins associated with 14-3-3 sigma were identified, and four 14-3-3 sigma-interacted proteins: keratin 8, epidermal growth factor receptor (EGFR), small GTP-binding protein RAB7, and p53 were confirmed by coimmunoprecipitation and Wes...

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Targeted proteomic analysis of 14-3-3σ in nasopharyngeal carcinoma

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