TM6SF2 reduces lipid accumulation in vascular smooth muscle cells by inhibiting LOX-1 and CD36 expression

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成果类型：

期刊论文

作者：

Li, Ting -Ting;Cui, Yu -Ting;Li, Tao-Hua;Xiang, Qiong;Chen, Yan-yu;...

通讯作者：

Peng, Juan;Tang, ZH

作者机构：

[Peng, Juan; Tang, Zhi-Han; Li, Ting -Ting; Xiang, Qiong; Cui, Yu -Ting; Li, Tao-Hua; Chen, Yan-yu; Tang, ZH] Univ South China, Hengyang Med Sch, Hunan Int Sci & Technol Cooperat Base Arterioscler, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

[Li, Tao-Hua] Hengyang Cent Hosp, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi -Long] Univ Calgary, Libin Cardiovasc Inst Alberta, Cumming Sch Med, Dept Biochem & Mol Biol, Calgary, AB, Canada.

[Tang, Zhi-Han; Tang, ZH] Univ South China, Inst Cardiovasc Dis, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Peng, J; Tang, ZH ] U

Univ South China, Hengyang Med Sch, Hunan Int Sci & Technol Cooperat Base Arterioscler, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan P, Hengyang 421001, Hunan, Peoples R China.

Univ South China, Inst Cardiovasc Dis, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Atherosclerotic cardiovascular disease;Human vascular smooth muscle cells;Lipid accumulation;Oxidized low-density lipoprotein;Transmembrane 6 superfamily 2

期刊：

Experimental Cell Research

ISSN：

0014-4827

年：

2023

卷：

429

期：

页码：

113666

DOI：

10.1016/j.yexcr.2023.113666

基金类别：

CRediT authorship contribution statement Ting-Ting Li: Data curation. Yu-Ting Cui: Writing – original draft. Tao-Hua Li: Data curation. Qiong Xiang: Data curation. Yan-yu Chen: Data curation. Xi-Long Zheng: Writing – review & editing. Juan Peng: Conceptualization, acquisition. Zhi-Han Tang: Conceptualization, acquisition, Writing – review & editing.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

TM6SF2, predominantly expressed in the liver and intestine, is closely associated with lipid metabolism. We have demonstrated the presence of TM6SF2 in VSMCs within human atherosclerotic plaques. Subsequent functional studies were conducted to investigate its role in lipid uptake and accumulation in human vascular smooth muscle cells (HAVSMCs) using siRNA knockdown and overexpression techniques. Our results showed that TM6SF2 reduced lipid accumulation in oxLDL-stimulated VSMCs, likely through the regulation of lectin-like oxLDL receptor 1 (LOX...

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TM6SF2 reduces lipid accumulation in vascular smooth muscle cells by inhibiting LOX-1 and CD36 expression

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