Mechanisms and regulation of defensins in host defense

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成果类型：

期刊论文

作者：

Fu, Jie;Zong, Xin;Jin, Mingliang;Min, Junxia;Wang, Fudi;...

通讯作者：

Wang, YZ;Wang, FD

作者机构：

[Fu, Jie; Zong, Xin; Jin, Mingliang; Wang, Yizhen; Wang, YZ] Zhejiang Univ, Coll Anim Sci, Key Lab Mol Anim Nutr, Minist Educ, Hangzhou, Peoples R China.

[Fu, Jie; Zong, Xin; Jin, Mingliang; Wang, Yizhen; Wang, YZ] Minist Agr, Key Lab Anim Nutr & Feed Sci Eastern China, Hangzhou, Zhejiang, Peoples R China.

[Min, Junxia] Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Sch Med, Hangzhou 310058, Peoples R China.

[Wang, Fudi] Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, State Key Lab Expt Hematol,Sch Med, Hangzhou, Peoples R China.

[Wang, Fudi] Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang, Peoples R China.

通讯机构：

[Wang, FD ; Wang, YZ ] Z

Zhejiang Univ, Coll Anim Sci, Key Lab Mol Anim Nutr, Minist Educ, Hangzhou, Peoples R China.

Minist Agr, Key Lab Anim Nutr & Feed Sci Eastern China, Hangzhou, Zhejiang, Peoples R China.

Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, State Key Lab Expt Hematol,Sch Med, Hangzhou, Peoples R China.

Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang, Peoples R China.

语种：

英文

期刊：

信号转导与靶向治疗

ISSN：

2095-9907

年：

2023

卷：

期：

页码：

300

DOI：

10.1038/s41392-023-01553-x

基金类别：

Zhejiang Provincial Key Ramp;D Program of China [2021C02008]; China Agriculture Research System of MOF and MARA [CARS-35]; National Natural Science Foundation of China [32002185, 31930057, U21A20249]; National Key Ramp;D Program [2018YFA0507802]; Taishan Industrial Leading Talents Project; National Center of Technology Innovation for Pigs

机构署名：

本校为通讯机构

院系归属：

公共卫生学院

摘要：

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions in innate immunity, as well as their structure and activity relationships, along with their mechanisms of action and therapeutic potential, have been of great interest in recent years. To highlight the key research into the role of defensins in human and animal health, we first describe their research history, structural features, evolution, and antimicrobial mechanisms. Next, we cover the role of defensins ...

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