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Advances in β-diketocyclisation of curcumin derivatives and their Antitumor Activity

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成果类型:
期刊论文
作者:
Dai, Hailong;Zhang, Si;Zheng, Xing;Luo, Zhongqin;Chen, Hongfei*;...
通讯作者:
Chen, Hongfei;Yao, X
作者机构:
[Chen, Hongfei; Yao, Xu; Dai, Hailong; Zheng, Xing] Univ South China, Hengyang Med Sch, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
[Zhang, Si; Zheng, Xing] Hunan Vocat Coll Sci & Technol, Dept Pharm, Third ZhongyiShan Rd, Changsha 410004, Hunan, Peoples R China.
[Luo, Zhongqin] Shaoyang Hosp TCM, 631 Dongda Rd, Shaoyang 422000, Hunan, Peoples R China.
通讯机构:
[Chen, HF; Yao, X ] U
Univ South China, Hengyang Med Sch, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Antitumor;Structural modification;curcumin derivatives;heterocyclization;β-diketone
期刊:
Chemistry & Biodiversity
ISSN:
1612-1872
年:
2024
卷:
21
期:
2
页码:
e202301556-
基金类别:
Hunan Province Education Department; Hunan Provincial Hengyang Joint Fund [2020JJ6052, 202150083704]; [18 C0438]
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
AbstractCurcumin, derived from the popular spice turmeric, is a pharmacologically active polyphenol. Curcumin's therapeutic activity has been extensively studied in recent decades, with reports implicating curcumin in many biological activities, particularly, its significant anticancer activity. However, its potential as an oral administration product is hampered by poor bioavailability, which is associated with a variety of factors, including low water solubility, poor intestinal permeability, instability, and degradation at alkaline pH. To im...

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