Synthesis of novel amino acid derivatives containing chrysin as anti-tumor agents against human gastric carcinoma MGC-803 cells

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成果类型：

期刊论文

作者：

Song, Xiudao;Liu, Yunmei*;Ma, Jin;He, Jun;Zheng, Xing;...

通讯作者：

Liu, Yunmei

作者机构：

[Liu, Yunmei; Lei, Xiaoyong; Song, Xiudao; Zheng, Xing] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Zhang, Lurong; Song, Xiudao; Jiang, Guorong] Suzhou Acad Wumen Chinese Med, Suzhou Hosp Tradit Chinese Med, Suzhou 215003, Peoples R China.

[Ma, Jin] Soochow Univ, Affiliated Childrens Hosp, Suzhou 215003, Peoples R China.

[He, Jun] Univ South China, Inst Chem & Chem Engn, Hengyang 421001, Peoples R China.

通讯机构：

[Liu, Yunmei] U

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Chrysin;Amino acid derivatives;Apoptotic;Anti-proliferative

期刊：

Medicinal Chemistry Research

ISSN：

1054-2523

年：

2015

卷：

期：

页码：

1789-1798

DOI：

10.1007/s00044-014-1267-7

基金类别：

Construct Program of the Key Discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Abstract Two series of amino acid derivatives containing chrysin were prepared from 7-O-carboxymethyl chrysin (4a) and 7-O-carboxypropyl chrysin (4b) and amino acid methyl esters by treatment with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxybenzotriazole as coupling reagents. The anti-proliferative activities of these derivatives in vitro against human gastric carcinoma MGC-803 cells were evaluated by the standard MTT method. The results showed that among these derivatives tested, compound N-[4-(5-hydroxy-4-oxo-2-ph...

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Synthesis of novel amino acid derivatives containing chrysin as anti-tumor agents against human gastric carcinoma MGC-803 cells

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